Evidence map›Paper›PMID 38304834›Full record

ArticleHeliyon2024

High diagnostic accuracy of quantitative SARS-CoV-2 spike-binding-IgG assay and correlation with

Noriko Iwamoto, Yuki Takamatsu, Yusuke Asai, Kiyoto Tsuchiya, Kouki Matsuda, Yusuke Oshiro, Natsumi Inamura, Mari Terada, Takashi Nemoto, Moto Kimura and 5 more

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Noriko IwamotoDepartment of Disease Control Center, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Yuki TakamatsuRefractory Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Yusuke AsaiDepartment of Disease Control Center, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Kiyoto TsuchiyaAIDS Clinical Center, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Kouki MatsudaRefractory Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Yusuke OshiroClinical Laboratory Department, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Natsumi InamuraClinical Laboratory Department, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Mari TeradaDepartment of Disease Control Center, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Takashi NemotoClinical Laboratory Department, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Moto KimuraCenter for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Sho SaitoDepartment of Disease Control Center, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Shinichiro MoriokaDepartment of Disease Control Center, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Maeda KenjiRefractory Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Hiroaki MitsuyaRefractory Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Norio OhmagariDepartment of Disease Control Center, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
National Center for Global Health and Medicine · JPKagoshima University · JPNational Institutes of Health · US

Funding

Development of therapeutics for SARS-CoV-2 infectionZIABC012018 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MITSUYA, HIROAKI · 2020 to 2025
$2.6M
6 · The paper itself

Abstract

Background: Antibody testing can easily evaluate the clinical status of patients, aid in the diagnosis of multisystem inflammatory syndrome, and monitor the immunity level in the population. However, the applicability of serological tests in detecting antibodies against the severe acute respiratory syndrome 2 (SARS-CoV-2) spike-binding protein remains limited. This study aimed to quantify both serum-derived neutralizing immunoglobulin-G (IgG) antibody activity and the amount of anti-SARS-CoV-2 Spike-IgG (S-IgG) in convalescent sera/plasmas and evaluate the direct correlation between the Methods: We evaluated the neutralizing activity of purified IgG (IgG-EC Results: A high correlation was observed between S-IgG and IgG-EC Conclusions: Quantitative S-IgG tests are a useful and convenient tool for estimating

Indexed as

COVID-19Diagnostic toolsNeutralizing antibodyQuantitative anti-SARS-CoV-2-spike-IgG antibody testSARS-CoV-2

Identifiers

PMID38304834
PMCPMC10831606
OpenAlexW4390842173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.