Evidence map›Paper›PMID 38304625›Full record

ArticleCytotechnology2024

Pulsed electrical stimulation and amino acid derivatives promote collagen gene expression in human dermal fibroblasts.

Hiroya Urabe, Ryuji Akimoto, Shohei Kamiya, Katsu Hosoki, Hideyuki Ichikawa, Toshio Nishiyama

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hiroya UrabeHomer Ion Laboratory Co., Ltd, 17-2 Shinsen-cho, Shibuya-ku, Tokyo, 150-0045 Japan.ORCID 0000-0003-0145-7005
Ryuji AkimotoHomer Ion Laboratory Co., Ltd, 17-2 Shinsen-cho, Shibuya-ku, Tokyo, 150-0045 Japan.
Shohei KamiyaHomer Ion Laboratory Co., Ltd, 17-2 Shinsen-cho, Shibuya-ku, Tokyo, 150-0045 Japan.
Katsu HosokiHomer Ion Laboratory Co., Ltd, 17-2 Shinsen-cho, Shibuya-ku, Tokyo, 150-0045 Japan.
Hideyuki IchikawaHomer Ion Laboratory Co., Ltd, 17-2 Shinsen-cho, Shibuya-ku, Tokyo, 150-0045 Japan.
Toshio NishiyamaHomer Ion Laboratory Co., Ltd, 17-2 Shinsen-cho, Shibuya-ku, Tokyo, 150-0045 Japan.
Shibuya (Japan) · JPShinEtsu Chemical (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several collagen types are important for maintaining skin structure and function. Previous reports show that l-hydroxyproline (Hyp), N-acetyl-l-hydroxyproline (AHyp), and l-alanyl-l-glutamine (Aln-Gln) are biological active substances with collagen synthesis-promoting effects. In this study, we combined the promotive effects of pulsed electrical stimulation (PES) with three amino acid derivatives in human dermal fibroblasts. Fibroblasts were exposed to PES with a 4,800 Hz pulse frequency and a voltage at 1 or 5 V for 15 min. The gene expression of type I and III collagen (fibrillar collagen), type IV and VII collagen (basement membrane collagen and anchoring fibril collagen) were measured by RT-PCR 48 h after PES. PES alone promoted the expression of

Indexed as

Amino acid derivativesCollagen geneFibroblastsPulsed electrical stimulation

Identifiers

PMID38304625
PMCPMC10828296
OpenAlexW4388540666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.