Evidence map›Paper›PMID 38304521›Full record

ArticleJournal of oral and maxillofacial pathology : JOMFP

Minichromosome maintenance protein 5 - a promising prognostic marker of oral epithelial dysplasias and oral squamous cell carcinomas.

Lisha Mathew, Mahija Janardhanan, Rakesh Suresh, Vindhya Savithri, Thara Aravind, A Aiswarya

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Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Lisha MathewDepartment of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS Campus, Amrita University, Kochi, Kerala, India.
Mahija JanardhananDepartment of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS Campus, Amrita University, Kochi, Kerala, India.
Rakesh SureshDepartment of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS Campus, Amrita University, Kochi, Kerala, India.
Vindhya SavithriDepartment of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS Campus, Amrita University, Kochi, Kerala, India.
Thara AravindDepartment of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS Campus, Amrita University, Kochi, Kerala, India.
A AiswaryaDepartment of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS Campus, Amrita University, Kochi, Kerala, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early diagnosis is the single most effective means of reducing the mortality rate of oral cancer. Aim: This study was undertaken to assess the expression of minichromosome maintenance protein 5 (MCM5) in oral epithelial dysplasias and oral squamous cell carcinomas (OSCCs) and to evaluate their possible role as a biomarker for early diagnosis and prognosis of OSCC. Design: A retrospective cross-sectional study. Materials and Methods: The study was conducted to assess the expression of MCM5 immunohistochemically in the tissue samples of oral epithelial dysplasias ( Statistical Analysis: The difference in the mean nuclear labelling index (LI) between the groups and the subgroups was analysed statistically using the Kruskal-Wallis test and the Results: A progressive increase in the nuclear expression of MCM5 protein ( Conclusion: Our findings suggest that MCM5 may be of great value in assessing the malignant potential of dysplastic lesions and may serve as biomarker of utility in the early diagnosis and prognosis of OSCC.

Indexed as

Epithelial dysplasiaMCM5oral squamous cell carcinoma

Identifiers

PMID38304521
PMCPMC10829438

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