Evidence map›Paper›PMID 38304433›Full record

ArticleFrontiers in immunology2024

Complement activation and cellular inflammation in Fabry disease patients despite enzyme replacement therapy.

Björn Laffer, Malte Lenders, Elvira Ehlers-Jeske, Karin Heidenreich, Eva Brand, Jörg Köhl

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Björn LafferInstitute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.
Malte LendersDepartment of Internal Medicine D, University Hospital Münster, Münster, Germany.
Elvira Ehlers-JeskeInstitute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.
Karin HeidenreichEleva GmbH, Freiburg, Germany.
Eva BrandDepartment of Internal Medicine D, University Hospital Münster, Münster, Germany.
Jörg KöhlInstitute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.
University Hospital Münster · DEUniversity of Lübeck · DECincinnati Children's Hospital Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defective α-galactosidase A (AGAL/GLA) due to missense or nonsense mutations in the

Indexed as

Fabry DiseaseAntibodiesCodon, NonsenseComplement ActivationEnzyme Replacement TherapyHumansKidneyMaleAntibodiesCodon, NonsenseC3aC5acomplementenzyme replacement therapyFabry disease

Identifiers

PMID38304433
PMCPMC10830671
OpenAlexW4390980275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.