Evidence map›Paper›PMID 38303912›Full record

ReviewFrontiers in bioengineering and biotechnology2024

Nanotechnology-based non-viral vectors for gene delivery in cardiovascular diseases.

Liping Jiao, Zhuokai Sun, Zhihong Sun, Jie Liu, Guanjun Deng, Xiaozhong Wang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Liping Jiao *The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Zhuokai Sun *Queen Mary School, Nanchang University, Nanchang, China.
Zhihong SunThe Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Jie LiuThe Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Guanjun DengSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, Shenzhen, China.
Xiaozhong WangThe Second Affiliated Hospital of Nanchang University, Nanchang, China.
Qingdao University · CNYuhuangding Hospital · CNSecond Affiliated Hospital of Nanchang University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene therapy is a technique that rectifies defective or abnormal genes by introducing exogenous genes into target cells to cure the disease. Although gene therapy has gained some accomplishment for the diagnosis and therapy of inherited or acquired cardiovascular diseases, how to efficiently and specifically deliver targeted genes to the lesion sites without being cleared by the blood system remains challenging. Based on nanotechnology development, the non-viral vectors provide a promising strategy for overcoming the difficulties in gene therapy. At present, according to the physicochemical properties, nanotechnology-based non-viral vectors include polymers, liposomes, lipid nanoparticles, and inorganic nanoparticles. Non-viral vectors have an advantage in safety, efficiency, and easy production, possessing potential clinical application value when compared with viral vectors. Therefore, we summarized recent research progress of gene therapy for cardiovascular diseases based on commonly used non-viral vectors, hopefully providing guidance and orientation for future relevant research.

Indexed as

cardiovascular diseasegene therapygene transfernanotechnologynon-viral vector

Identifiers

PMID38303912
PMCPMC10830866
OpenAlexW4390980871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.