Evidence map›Paper›PMID 38303720›Full record

ArticleiScience2024

Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men.

Pei-Ying Wu, Michelle Van Scoyk, Stephanie S McHale, Chu-Fang Chou, Gregory Riddick, Kamran Farouq, Bin Hu, Vita Kraskauskiene, Jennifer Koblinski, Charles Lyons and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Pei-Ying WuMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Michelle Van ScoykMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Stephanie S McHaleMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Chu-Fang ChouMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Gregory RiddickMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Kamran FarouqMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Bin HuDepartment of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Vita KraskauskieneDepartment of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Jennifer KoblinskiDepartment of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Charles LyonsDepartment of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Arjun RijalDepartment of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Vignesh VudathaDivision of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Dongyu ZhangDivision of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Jose G TrevinoDivision of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Rachit D ShahDivision of Cardiothoracic Surgery, Virginia Commonwealth University, Richmond, VA, USA.
Patrick Nana-SinkamDivision of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Yong HuangDivision of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA.
Shwu-Fan MaDivision of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA.
Imre NothDivision of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA.
Chanita Hughes-HalbertNorris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Victoria L SeewaldtCity of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Ching-Yi ChenMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Robert A WinnMassey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Virginia Commonwealth University · USUniversity of Virginia · USCity of Hope · USUniversity of Southern California · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
United for Health Excellence - Living PDX Program (U4HELPP)U54CA283762 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI JENNIFER E KOBLINSKI · 2023 to 2026
$5.0M
Translational Research Center in Lung Cancer Disparities (TRACER)P20CA252717 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI NANASINKAM, SERGE PATRICK · 2021 to 2023
$3.2M
Architectural structure and regulation of TOLLIP in IPFR01HL130796 · NHLBI · UNIVERSITY OF VIRGINIA · PI NOTH, IMRE · 2016 to 2019
$3.1M
1/2 Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases studyUG3HL145266 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARTINEZ, FERNANDO J, NOTH, IMRE · 2019 to 2019
$977k
NCI NIH HHS P20 CA252717NCI NIH HHS P30 CA016059NCI NIH HHS U54 CA283762NHLBI NIH HHS R01 HL130796NHLBI NIH HHS UG3 HL145266
6 · The paper itself

Abstract

Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.

Indexed as

CancerHealth disparityMolecular biology

Identifiers

PMID38303720
PMCPMC10830871
OpenAlexW4390754356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.