Evidence map›Paper›PMID 38303706›Full record

ArticleiScience2024

Ultrasound-targeted microbubble technology facilitates SAHH gene delivery to treat diabetic cardiomyopathy by activating AMPK pathway.

Xiaohui Guo, Kegong Chen, Lin Ji, Shanjie Wang, Xiangmei Ye, Liang Xu, Leiguang Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiaohui GuoDepartment of Clinical Laboratory, First Affiliated Hospital of Harbin Medical University, Harbin 150081, P.R. China.
Kegong ChenDepartment of Thoracic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230022, P.R. China.
Lin JiDepartment of Orthopedics, The First Hospital of Harbin, Harbin 150010, P.R. China.
Shanjie WangThe Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150086, P.R. China.
Xiangmei YeDepartment of Clinical Laboratory, First Affiliated Hospital of Harbin Medical University, Harbin 150081, P.R. China.
Liang XuDepartment of Cardiology, The Second Hospital of Harbin, Harbin 150056, P.R. China.
Leiguang FengDepartment of Clinical Laboratory, First Affiliated Hospital of Harbin Medical University, Harbin 150081, P.R. China.
Harbin Medical University · CNMinistry of Education of the People's Republic of China · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM) is a cardiovascular complication with no known cure. In this study, we evaluated the combination of ultrasound-targeted microbubble destruction (UTMD) and cationic microbubbles (CMBs) for cardiac S-adenosyl homocysteine hydrolase (SAHH) gene transfection as potential DCM therapy. Models of high glucose/fat (HG/HF)-induced H9C2 cells and streptozotocin-induced DCM rats were established. Ultrasound-mediated

Indexed as

Biological sciencesBiotechnologyCardiovascular medicineMolecular biology

Identifiers

PMID38303706
PMCPMC10831940
OpenAlexW4390748549

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.