Evidence map›Paper›PMID 38303696›Full record

ArticleiScience2024

Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis.

Kathryn A Bowman, Christine D Wiggins, Elizabeth DeRiso, Steffan Paul, Klemen Strle, John A Branda, Allen C Steere, Douglas A Lauffenburger, Galit Alter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Kathryn A BowmanRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Christine D WigginsDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Elizabeth DeRisoRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Steffan PaulMarks Group, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Klemen StrleTufts University School of Medicine Boston, Boston, MA, USA.
John A BrandaDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Allen C SteereCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Douglas A LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Galit AlterRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Harvard University · USMassachusetts Institute of Technology · USRagon Institute of MGH, MIT and Harvard · USBrigham and Women's Hospital · USMassachusetts General Hospital · USTufts University · US

Funding

Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
Cellular and humoral immunity in Lyme arthritisR01AI144365 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI STEERE, ALLEN C · 2019 to 2023
$2.9M
NIAID NIH HHS R01 AI144365NIAID NIH HHS T32 AI007387
6 · The paper itself

Abstract

Lyme arthritis, caused by the spirochete

Indexed as

Health sciencesImmunologyMicrobiology

Identifiers

PMID38303696
PMCPMC10830897
OpenAlexW4390590955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.