Evidence map›Paper›PMID 38303501›Full record

ArticleGut microbes

Microbiome function and neurodevelopment in Black infants: vitamin B

Kaitlyn Oliphant, Wilfredo Cruz Ayala, Rimma Ilyumzhinova, Kimberley Mbayiwa, Anna Sroka, Bingqing Xie, Bree Andrews, Kate Keenan, Erika C Claud

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kaitlyn OliphantDepartment of Pediatrics, University of Chicago, Chicago, USA.
Wilfredo Cruz AyalaDepartment of Pediatrics, University of Chicago, Chicago, USA.
Rimma IlyumzhinovaDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.
Kimberley MbayiwaDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.
Anna SrokaDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.
Bingqing XieDepartment of Medicine, University of Chicago, Chicago, USA.
Bree AndrewsDepartment of Pediatrics, University of Chicago, Chicago, USA.
Kate KeenanDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.
Erika C ClaudDepartment of Pediatrics, University of Chicago, Chicago, USA.
University of Chicago · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
The Gut Microbiome Brain Axis and Preterm InfantsR01HD105234 · NICHD · UNIVERSITY OF CHICAGO · PI CLAUD, ERIKA C · 2021 to 2025
$3.4M
Improving maternal and child health through prenatal fatty acid supplementation: A randomized controlled study in African American women living in low-income urban environmentsR01HD084586 · NICHD · UNIVERSITY OF CHICAGO · PI KEENAN, KATHRYN ELIZABETH · 2015 to 2020
$3.0M
Probing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1M
NICHD NIH HHS R01 HD084586NICHD NIH HHS R01 HD105234NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK138072NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

The early life gut microbiome affects the developing brain, and therefore may serve as a target to support neurodevelopment of children living in stressful and under-resourced environments, such as Black youth living on the South Side of Chicago, for whom we observe racial disparities in health. Microbiome compositions/functions key to multiple neurodevelopmental facets have not been studied in Black children, a vulnerable population due to racial disparities in health; thus, a subsample of Black infants living in urban, low-income neighborhoods whose mothers participated in a prenatal nutrition study were recruited for testing associations between composition and function of the gut microbiome (16S rRNA gene sequencing, shotgun metagenomics, and targeted metabolomics of fecal samples) and neurodevelopment (developmental testing, maternal report of temperament, and observed stress regulation). Two microbiome community types, defined by high

Indexed as

Gastrointestinal MicrobiomeVitamin B 12AdolescentBrainChildFemaleHumansInfantMalePregnancyRNA, Ribosomal, 16SVitaminsRNA, Ribosomal, 16SVitamin B 12VitaminsBlack infantHealth disparitiesMicrobiomeNeurodevelopmentVitamin B12

Identifiers

PMID38303501
PMCPMC10841033
OpenAlexW4391480520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.