Evidence map›Paper›PMID 38303018›Full record

ReviewJournal of experimental & clinical cancer research : CR2024

T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution.

Wenhui Yang, Shimao Liu, Mengyun Mao, Yandong Gong, Xiaohui Li, Tianyu Lei, Chao Liu, Shikai Wu, Qinyong Hu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of experimental & clinical cancer research : CR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 69 citations in OpenAlex.

  1. Trial
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  6. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wenhui Yang *Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Shimao Liu *Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Mengyun Mao *Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Yandong GongState Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China.
Xiaohui LiDepartment of Medical Oncology, Peking University First Hospital, Beijing, 100034, China.
Tianyu LeiDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Chao LiuDepartment of Radiation Oncology, Peking University First Hospital, Beijing, 100034, China. charles_liu@hsc.pku.edu.cn.ORCID http://orcid.org/0000-0002-3807-9901
Shikai WuDepartment of Medical Oncology, Peking University First Hospital, Beijing, 100034, China. skywu4923@sina.com.
Qinyong HuDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. rm001223@whu.edu.cn.
Wuhan University · CNPeking University · CNChinese PLA General Hospital · CN

Funding

Hubei Province Big Health Industry Development Special Fund 2019916000001National Natural Science Foundation of China 81670144
6 · The paper itself

Abstract

Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand tumor immunity and improve therapeutic effect of cancer immunotherapy. The use of single-cell RNA sequencing (scRNA-seq) allows the high-resolution analysis of the precise composition of immune cells with different phenotypes and other microenvironmental factors, including non-immune stromal cells and the related molecules in the tumor microenvironment of various cancer types. In this review, we summarized the research progress on T-cell infiltration and the crosstalk of other stromal cells and cytokines during T-cell infiltration using scRNA-seq to provide insights into the mechanisms regulating T-cell infiltration and contribute new perspectives on tumor immunotherapy.

Indexed as

NeoplasmsT-LymphocytesCytokinesHumansImmunotherapyPhenotypeSingle-Cell AnalysisTumor MicroenvironmentCytokines“hot tumors” and “cold tumors”Single-cell RNA sequencingStromal cellsT-cell infiltrationTumor microenvironment

Identifiers

PMID38303018
PMCPMC10835979
OpenAlexW4391482791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.