Evidence map›Paper›PMID 38303002›Full record

ArticleBMC complementary medicine and therapies2024

Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats.

Ragaa Sm Kawara, Fatma Sm Moawed, Yakout Elsenosi, Hussein Abd Elmaksoud, Esraa S A Ahmed, Omayma Ar Abo-Zaid

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ragaa Sm KawaraBiochemistry and Molecular Biology Department, Faculty of Vet. Med, Benha University, Banha, Egypt.
Fatma Sm MoawedHealth radiation research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Nasr City, 11787, Cairo, Egypt.ORCID http://orcid.org/0000-0002-5792-0815
Yakout ElsenosiBiochemistry and Molecular Biology Department, Faculty of Vet. Med, Benha University, Banha, Egypt.
Hussein Abd ElmaksoudBiochemistry and Molecular Biology Department, Faculty of Vet. Med, Benha University, Banha, Egypt.
Esraa S A AhmedRadiation Biology Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Nasr City, 11787, Cairo, Egypt. esraa.tamim@yahoo.com.ORCID http://orcid.org/0000-0001-5358-4394
Omayma Ar Abo-ZaidBiochemistry and Molecular Biology Department, Faculty of Vet. Med, Benha University, Banha, Egypt.ORCID http://orcid.org/0000-0002-1752-6709
Benha University · EGEgyptian Atomic Energy Authority · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMelissa officinalis (MO) is a well-known medicinal plant species used in the treatment of several diseases; it is widely used as a vegetable, adding flavour to dishes. This study was designed to evaluate the therapeutic effect of MO Extract against hyperthyroidism induced by Eltroxin and γ-radiation.

methodsHyperthyroidism was induced by injecting rats with Eltroxin (100 µg/kg/ day) for 14 days and exposure to γ-radiation (IR) (5 Gy single dose). The hyperthyroid rats were orally treated with MO extract (75 mg/kg/day) at the beginning of the second week of the Eltroxin injection and continued for another week. The levels of thyroid hormones, liver enzymes and proteins besides the impaired hepatic redox status and antioxidant parameters were measured using commercial kits. The hepatic gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein-1(Keap-1) in addition to hepatic inflammatory mediators including tumor necrosis factor-α (TNF- α), Monocyte chemoattractant protein-1 (MCP-1) and fibrogenic markers such as transforming growth factor-beta1 (TGF-β1) were determined.

resultsMO Extract reversed the effect of Eltroxin + IR on rats and attenuated the thyroid hormones. Moreover, it alleviated hyperthyroidism-induced hepatic damage by inhibiting the hepatic enzymes' activities as well as enhancing the production of proteins concomitant with improving cellular redox homeostasis by attenuating the deranged redox balance and modulating the Nrf2/Keap-1 pathway. Additionally, MO Extract alleviated the inflammatory response by suppressing the TNF- α and MCP-1 and prevented hepatic fibrosis via Nrf2-mediated inhibition of the TGF-β1/Smad pathway.

conclusionAccordingly, these results might strengthen the hepatoprotective effect of MO Extract in a rat model of hyperthyroidism by regulating the Nrf-2/ Keap-1 pathway.

Indexed as

HyperthyroidismLiver DiseasesMelissaPlant ExtractsAnimalsGene ExpressionInflammationLiverNF-E2-Related Factor 2Oxidation-ReductionRatsThyroid HormonesThyroxineTransforming Growth Factor beta1NF-E2-Related Factor 2Plant ExtractsThyroid HormonesThyroxineTransforming Growth Factor beta1HyperthyroidismInflammationLiver damageMelissa officinalisNrf2/Keap1

Identifiers

PMID38303002
PMCPMC10832092
OpenAlexW4391448716

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.