ReviewSystematic reviews2024
Minimal clinically important change of knee flexion in people with knee osteoarthritis after non-surgical interventions using a meta-analytical approach.
Review in Systematic reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Alignment strategy does not confer clinically meaningful advantages in medial pivot total knee arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Pooled it
- Kinematic Alignment Does Not Result in Clinically Important Improvements After TKA Compared With Mechanical Alignment: A Meta-analysis of Randomized Trials.Clinical orthopaedics and related research · 2025Pooled it
- Efficacy of Active Exercises to Improve Range of Motion in Knee Joint After Total Knee Arthroplasty. A Randomized Controlled Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Trial
- Medial Unicompartmental Versus Total Knee Arthroplasty in the Treatment of Isolated Anteromedial Knee Osteoarthritis: Two-Year Results from a Double-Blinded, Multicenter, Randomized Trial of 350 Patients.The Journal of bone and joint surgery. American volume · 2026Trial
- Physical therapy vs. glucocorticoid injection in patients with meniscal tears and knee osteoarthritis: a multi-center, randomized, controlled trial.BMC medicine · 2025Trial
- EMMATKA trial: the effects of mobilization with movement following total knee arthroplasty in women: a single-blind randomized controlled trial.Journal of orthopaedic surgery and research · 2025Trial
- Greater knee flexion and patient-reported function after unicompartmental knee arthroplasty than after total knee arthroplasty: a propensity score-matched study.International orthopaedics · 2026Article
- Does physical therapist contact matter? A randomised controlled trial comparing telerehabilitation and booklet-based exercise for knee osteoarthritis.European journal of translational myology · 2026Article
- A Simple Minimum-Setup Pipeline for Using Leg-Worn Inertial Sensors to Track Knee Flexion: Validation on 10 Movements.Sensors (Basel, Switzerland) · 2026Article
- Migration in unicompartmental knee arthroplasty with the Persona Partial Knee: a cohort study of 26 patients using radiostereometry with 60 months of follow-up.Acta orthopaedica · 2026Article
- Validating Single-Camera Pose Estimation Against Multi-Camera Motion Capture for Accessible Biomechanical Assessment.IEEE access : practical innovations, open solutions · 2026Article
- Functional versus mechanical alignment in robotic primary total knee arthroplasty: A meta-analysis.SICOT-J · 2026Article
- Dual-Camera Markerless Motion Capture System for Precise Lower-Limb Kinematic Analysis in Osteoarthritis.Annals of biomedical engineering · 2025Article
- No difference in revision rate in patella-friendly total knee arthroplasty with or without patella resurfacing at 5 years' follow-up. A database analysis.Journal of experimental orthopaedics · 2025Article
- No difference in 5-year survivorship between cemented versus cementless total knee arthroplasty in a cohort of 5266 patients using a deep-dish mobile bearing implant.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Predictors of post-operative decline in knee flexion after cruciate-retaining total knee arthroplasty.Journal of experimental orthopaedics · 2025Article
- Quantification of Lower Limb Kinematics During Swimming in Individuals with Spinal Cord Injury.Sensors (Basel, Switzerland) · 2025Article
- The biomechanical and functional outcomes of fresh osteochondral allograft for the knee: A systematic review.Journal of clinical orthopaedics and trauma · 2025Review
- Effect of laser acupuncture on pain, range of motion, and function in patellofemoral pain syndrome: a randomised controlled trial.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMinimal clinically important change (MCIC) represents the minimum patient-perceived improvement in an outcome after treatment, in an individual or within a group over time. This study aimed to determine MCIC of knee flexion in people with knee OA after non-surgical interventions using a meta-analytical approach.
methodsFour databases (MEDLINE, Cochrane, Web of Science and CINAHL) were searched for studies of randomised clinical trials of non-surgical interventions with intervention duration of ≤ 3 months that reported change in (Δ) (mean change between baseline and immediately after the intervention) knee flexion with Δ pain or Δ function measured using tools that have established MCIC values. The risk of bias in the included studies was assessed using version 2 of the Cochrane risk-of-bias tool for randomised trials (RoB 2). Bayesian meta-analytic models were used to determine relationships between Δ flexion with Δ pain and Δ function after non-surgical interventions and MCIC of knee flexion.
resultsSeventy-two studies (k = 72, n = 5174) were eligible. Meta-analyses included 140 intervention arms (k = 61, n = 4516) that reported Δ flexion with Δ pain using the visual analog scale (pain-VAS) and Δ function using the Western Ontario and McMaster Universities Osteoarthritis Index function subscale (function-WOMAC). Linear relationships between Δ pain at rest-VAS (0-100 mm) with Δ flexion were - 0.29 (- 0.44; - 0.15) (β: posterior median (CrI: credible interval)). Relationships between Δ pain during activity VAS and Δ flexion were - 0.29 (- 0.41, - 0.18), and Δ pain-general VAS and Δ flexion were - 0.33 (- 0.42, - 0.23). The relationship between Δ function-WOMAC (out of 100) and Δ flexion was - 0.15 (- 0.25, - 0.07). Increased Δ flexion was associated with decreased Δ pain-VAS and increased Δ function-WOMAC. The point estimates for MCIC of knee flexion ranged from 3.8 to 6.4°.
conclusionsThe estimated knee flexion MCIC values from this study are the first to be reported using a novel meta-analytical method. The novel meta-analytical method may be useful to estimate MCIC for other measures where anchor questions are problematic. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42022323927.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.