Evidence map›Paper›PMID 38302806›Full record

ArticleMolecular biology reports2024

Wnt10b knockdown regulates the relative balance of adipose tissue-resident T cells and inhibits white fat deposition.

Yan Liu, Geng Hu, Yanxin Jia, Lining Qin, Longfei Xu, Yaxin Chang, Bin Li, Haifang Li

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Frontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yan LiuCollege of Life Sciences, Shandong Agricultural University, Tai'an, 271018, China.
Geng HuCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.
Yanxin JiaCollege of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.
Lining QinCollege of Life Sciences, Shandong Agricultural University, Tai'an, 271018, China.
Longfei XuCollege of Life Sciences, Shandong Agricultural University, Tai'an, 271018, China.
Yaxin ChangCollege of Life Sciences, Shandong Agricultural University, Tai'an, 271018, China.
Bin LiCollege of Life Sciences, Shandong Agricultural University, Tai'an, 271018, China.
Haifang LiCollege of Life Sciences, Shandong Agricultural University, Tai'an, 271018, China. haifangli@sdau.edu.cn.
Shandong Agricultural University · CN

Funding

Key Technology Research and Development Program of Shandong Province 2019JZZY020602the Earmarked Fund for China Agriculture Research System CARS-40-K09the National Key Research and Development Program of China 2021YFD1300405
6 · The paper itself

Abstract

backgroundWnt10b is one of critical Wnt family members that being involved in networks controlling stemness, pluripotency and cell fate decisions. However, its role in adipose-resident T lymphocytes and further in fat metabolism yet remains largely unknown. METHODS AND

resultsIn the present study, we demonstrated a distinctive effect for Wnt10b on the relative balance of T lymphocytes in adipose tissue by using a Wnt10b knockdown mouse model. Wnt10b knockdown led to a reduction of adipose-resident CD4

conclusionsCollectively, we reveal an unexpected and novel function for Wnt10b in mediating the frequency of adipose-resident T cell subsets, that when knockdown skewing toward a Treg-dominated phenotype and further improving fat metabolism.

Indexed as

Adipose TissueAdipose Tissue, WhiteAdipogenesisAnimalsCell DifferentiationDiet, High-FatMiceMice, Inbred C57BLObesityWnt ProteinsWnt10b protein, mouseWnt ProteinsAdipogenesisAdipose tissue-resident T cellsTreg cellsWhite fat depositionWnt10b

Identifiers

PMID38302806
OpenAlexW4391423497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.