Evidence map›Paper›PMID 38302502›Full record

ArticleNature communications2024

Congenital heart disease detection by pediatric electrocardiogram based deep learning integrated with human concepts.

Jintai Chen, Shuai Huang, Ying Zhang, Qing Chang, Yixiao Zhang, Dantong Li, Jia Qiu, Lianting Hu, Xiaoting Peng, Yunmei Du and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Wearable Flexible Sensors for Cardiovascular Disease Monitoring.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Article
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  17. Article
  18. A Multi-Task Deep Learning Model for Pediatric Echocardiography Analysis.medRxiv : the preprint server for health sciences · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Jintai Chen *State Key Laboratory of Transvascular Implantation Devices of the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, 310009, Hangzhou, China.ORCID 0000-0002-3199-2597
Shuai Huang *Medical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong Province, China.
Ying Zhang *Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080, Guangzhou, Guangdong Province, China.
Qing Chang *Liaoning Engineering Research Center of Intelligent Diagnosis and Treatment Ecosystem, 110004, Shenyang, Liaoning Province, China.
Yixiao ZhangLiaoning Engineering Research Center of Intelligent Diagnosis and Treatment Ecosystem, 110004, Shenyang, Liaoning Province, China.
Dantong LiMedical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong Province, China.
Jia QiuGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080, Guangzhou, Guangdong Province, China.
Lianting HuMedical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong Province, China.
Xiaoting PengMedical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong Province, China.
Yunmei DuCollege of Information Technology and Engineering, Guangzhou College of Commerce, 510363, Guangzhou, Guangdong Province, China.
Yunfei GaoZhuhai Precision Medical Center, Zhuhai People's Hospital/ Zhuhai Hospital Affiliated with Jinan University, Jinan University, 519000, Zhuhai, Guangdong Province, China.
Danny Z ChenDepartment of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.ORCID 0000-0001-6565-2884
Abdelouahab BellouInstitute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080, Guangzhou, China. abellou402@gmail.com.
Jian WuState Key Laboratory of Transvascular Implantation Devices of the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, 310009, Hangzhou, China. wujian2000@zju.edu.cn.
Huiying LiangMedical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong Province, China. lianghuiying@hotmail.com.ORCID 0000-0002-9987-8002
Guangdong Academy of Medical Sciences · CNLiaoning University · CNSecond Affiliated Hospital of Zhejiang University · CNGuangzhou Women and Children Medical Center · CNJinan University · CNUniversity of Notre Dame · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early detection is critical to achieving improved treatment outcomes for child patients with congenital heart diseases (CHDs). Therefore, developing effective CHD detection techniques using low-cost and non-invasive pediatric electrocardiogram are highly desirable. We propose a deep learning approach for CHD detection, CHDdECG, which automatically extracts features from pediatric electrocardiogram and wavelet transformation characteristics, and integrates them with key human-concept features. Developed on 65,869 cases, CHDdECG achieved ROC-AUC of 0.915 and specificity of 0.881 on a real-world test set covering 12,000 cases. Additionally, on two external test sets with 7137 and 8121 cases, the overall ROC-AUC were 0.917 and 0.907 while specificities were 0.937 and 0.907. Notably, CHDdECG surpassed cardiologists in CHD detection performance comparison, and feature importance scores suggested greater influence of automatically extracted electrocardiogram features on CHD detection compared with human-concept features, implying that CHDdECG may grasp some knowledge beyond human cognition. Our study directly impacts CHD detection with pediatric electrocardiogram and demonstrates the potential of pediatric electrocardiogram for broader benefits.

Indexed as

Deep LearningHeart Defects, CongenitalChildCognitionElectrocardiographyHumans

Identifiers

PMID38302502
PMCPMC10834950
OpenAlexW4391451039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.