Evidence map›Paper›PMID 38302488›Full record

ArticleScientific reports2024

Comparative analysis of breast cancer characteristics in young premenopausal and postmenopausal women in Ghana.

Kingsley Bosompem, Joseph Yorke, Tonnies Abeku Buckman, Samuel Gyasi Brenu, Michael Nyantakyi, Francis Somiah-Kwaw Aitpillah, Ishmael Kyei, Michael Ofoe Adinku, Dennis Afful Yorke, Christian Obirikorang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kingsley BosompemDirectorate of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Joseph YorkeDepartment of Surgery, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Tonnies Abeku BuckmanDepartment of Medical Laboratory Science, KAAF University College, Buduburam, Ghana.
Samuel Gyasi BrenuDirectorate of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Michael NyantakyiDepartment of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Francis Somiah-Kwaw AitpillahDirectorate of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Ishmael KyeiDepartment of Surgery, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Michael Ofoe AdinkuDirectorate of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Dennis Afful YorkeDirectorate of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Christian ObirikorangDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Emmanuel AcheampongDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. emmanuelachea1990@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is increasingly common among young women in Ghana. BCa is heterogeneous with unique traits that impact causes, prognostic, and predictive outcomes of patients before and after menopause. However, limited evidence exists on differences between young premenopausal (YPM) and postmenopausal cases in Ghana. This study compared breast tumour characteristics between YPM women (under 35 years) and postmenopausal women. We conducted a prospective cross-sectional study involving 140 BCa-diagnosed women at the Breast Care Clinic of Komfo Anokye Teaching Hospital (KATH), Kumasi from November 2019 to June 2021. Thirty-one (22.1%) of participants were YPM and 109 (77.9%) were postmenopausal. The median ages for YPM and postmenopausal were 32.0 (range: 25.0-35.0) and 57.0 (48.0-86.0) respectively. Invasive carcinoma was the most common histological type (97.1%). Left tumour location was the most frequent in both groups (51.6% for YPM and 51.8% for postmenopausal). Lumps detected were frequently in the outer upper quadrant in both groups (61.3% and 56.0%). The majority of the YPM women (80.7%) and postmenopausal women (87.0%) had stage III and IV diseases. Most YPM (64.5%) and postmenopausal women (64.4%) exhibited triple-negative breast cancer (TNBC). Both YPM 13 (56.6%) and postmenopausal participants 40 (56.3%) exhibited a predominantly partial response to neo-adjuvant chemotherapy but YPM women (21.7%) experienced disease progression than the postmenopausal women (12.7%). The study highlights consistent tumour characteristics and advanced clinical stages at diagnosis in both groups with a higher prevalence of TNBC. TNBC and HER2+ subtypes respond better to Anthracycline-based neoadjuvant chemotherapy. Establishing Breast Care Clinics in district and regional hospitals for early detection is crucial and further studies are warranted to understand the higher TNBC prevalence in black Africans and re-evaluate breast education programs to address the persistently late presentations.

Indexed as

Breast NeoplasmsTriple Negative Breast NeoplasmsCross-Sectional StudiesErb-b2 Receptor Tyrosine KinasesFemaleGhanaHumansPostmenopauseProspective StudiesErb-b2 Receptor Tyrosine Kinases

Identifiers

PMID38302488
PMCPMC10834954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.