Evidence map›Paper›PMID 38302370›Full record

ArticleUltrasound in medicine & biology2024

Characterization of Blood-Brain Barrier Opening Induced by Transcranial Histotripsy in Murine Brains.

Sarah Duclos, Sang Won Choi, Anuska V Andjelkovic, Neeraj Chaudhary, Sandra Camelo-Piragua, Aditya Pandey, Zhen Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sarah DuclosDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: sduclos@umich.edu.
Sang Won ChoiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Anuska V AndjelkovicDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Neeraj ChaudharyDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Sandra Camelo-PiraguaDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Aditya PandeyDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Zhen XuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Novel, Noninvasive, Rapid Tumor Ablation Technology using HistotripsyR01CA211217 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, ZHEN · 2018 to 2022
$2.7M
Novel Ultrasonic Technique for the Treatment of Hemorrhagic StrokeR01NS108042 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PANDEY, ADITYA S · 2018 to 2022
$2.6M
Transcranial Magnetic Resonance guided Histotripsy (tcMRgHt)R01EB028309 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, ZHEN · 2019 to 2022
$2.4M
Novel Ultrasonic Technology to Treat Hemorrhagic StrokeR21NS093121 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, ZHEN · 2015 to 2016
$426k
Non-invasive Transcranial Histotripsy Treatment in a Murine Primary Malignant Brain Tumor ModelR21CA260684 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PANDEY, ADITYA S, XU, ZHEN · 2021 to 2021
$384k
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA211217NCI NIH HHS R21 CA260684NIBIB NIH HHS R01 EB028309NINDS NIH HHS R01 NS108042NINDS NIH HHS R21 NS093121
6 · The paper itself

Abstract

objectiveTranscranial histotripsy has shown promise as a non-invasive neurosurgical tool, as it has the ability to treat a wide range of locations in the brain without overheating the skull. One important effect of histotripsy in the brain is the blood-brain barrier (BBB) opening (BBBO) at the ablation site, but there is a knowledge gap concerning the extent of histotripsy-induced BBBO. Here we describe induction of BBBO by transcranial histotripsy and use of magnetic resonance imaging (MRI) and histology to quantify changes in BBBO at the periphery of the histotripsy ablation zone over time in the healthy mouse brain.

methodsAn eight-element, 1 MHz histotripsy transducer with a focal distance of 32.5 mm was used to treat the brains of 23 healthy female BL6 mice. T1-gadolinium (T1-Gd) MR images were acquired immediately following histotripsy treatment and during each of the subsequent 4 wk to quantify the size and intensity of BBB leakage.

resultsThe T1-Gd MRI results revealed that the hyperintense BBBO volume increased over the first week and subsided gradually over the following 3 wk. Histology revealed complete loss of tight junction proteins and blood vessels in the center of the ablation region immediately after histotripsy, partial recovery in the periphery of the ablation zone 1 wk following histotripsy and near-complete recovery of tight junction complex after 4 wk.

conclusionThese results provide the first evidence of transcranial histotripsy-induced BBBO and repair at the periphery of the ablation zone.

Indexed as

Blood-Brain BarrierHigh-Intensity Focused Ultrasound AblationAnimalsBrainFemaleLiverMiceSkullBlood–brain barrierClaudin-5GadoliniumHistologyHistotripsyMagnetic resonance imagingTight junction proteinTranscranialZO-1

Identifiers

PMID38302370
PMCPMC11894761
OpenAlexW4391427258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.