Evidence map›Paper›PMID 38302366›Full record

ArticleAmerican journal of surgery2024

Deficiencies in germline genetic testing in young-onset colorectal cancer patients.

Hannah Ficarino, Ben Cage, Jean Paul Osula, Alexis Heatherly, Daniel Chu, Sushanth Reddy, Smita Bhatia, Robert Hollis

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Young Onset Colorectal Cancer.South Asian journal of cancer · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah FicarinoDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: hficarino@uabmc.edu.
Ben CageHeersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: bbcage@uab.edu.
Jean Paul OsulaHeersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: josula27@uab.edu.
Alexis HeatherlyDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: acoates@uabmc.edu.
Daniel ChuDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Sushanth ReddyDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: sreddy@uabmc.edu.
Smita BhatiaInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: smitabhatia@uabmc.edu.
Robert HollisDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: rhhollis@uabmc.edu.

Funding

Surgical Oncology Research Training ProgramT32CA229102 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HERBERT CHEN · 2018 to 2026
$3.2M
NCI NIH HHS T32 CA229102
6 · The paper itself

Abstract

backgroundYoung-onset colorectal cancer (YO-CRC) patients have high rates of pathologic genetic variants on germline testing, however it is unclear what factors are associated with genetic testing completion.

methodsWe performed a retrospective review of YO-CRC patients aged ≤50 years between 2014 and 2021 who received the entirety of their cancer care at a single institution. The primary outcome was completion of germline multigene panel testing. Variables were examined for association with germline multigene panel testing.

resultsAmong 100 YO-CRC patients, only 31 ​% (n ​= ​31) completed genetic testing. Testing rates did not differ by colorectal cancer stage but were significantly higher among patients who received chemotherapy (39.8 ​% vs 5.9 ​%; p ​= ​0.01) and in patients with increasing number of relatives with a family history of cancer (p ​< ​0.01).

conclusionsOnly one-third of YO-CRC patients completed genetic testing. Patients seen by oncology or with increasingly strong family cancer history were more likely to complete genetic testing.

Indexed as

Age of OnsetColorectal NeoplasmsGenetic TestingGerm-Line MutationAdultFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedRetrospective StudiesYoung AdultColorectal cancerGenetic counselingGenetic testingYoung-onset

Identifiers

PMID38302366
PMCPMC11090699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.