Observational studyThe American journal of clinical nutrition2024
Metabolomics of Ramadan fasting and associated risk of chronic diseases.
Observational study in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Time-restricted eating, immunomodulation and ketone metabolism in humans.Metabolism: clinical and experimental · 2026Review
- Towards Metabolomics-Guided Healthy and Anti-Aging Nutrition.Metabolites · 2026Article
- Fasting as a Multisystem Health Modulator: A Narrative Review of Metabolic, Cardiovascular, Immune, Neurocognitive, and Psychospiritual Effects.Current nutrition reports · 2026Review
- When hunger and thirst part ways: a longitudinal comparison of men and women across the Ramadan fasting-recovery cycle, with non-fasting controls.Frontiers in nutrition · 2026Article
- Effects of Ramadan fasting on glycemic control and lipid profile in type 2 diabetes mellitus: a systematic review and meta-analysis of clinical studies.Journal of Yeungnam medical science · 2026Article
- Ramadan during pregnancy and the role of dietary intake for neonatal health in Kaduna, Northwestern Nigeria: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Body Weight Changes During Ramadan Intermittent Fasting: A Cross-Sectional Study of Healthy Adults in Turkey.Journal of nutrition and metabolism · 2025Article
- Ramadan Fasting and Its Impact on Patients With Chronic Kidney Disease: Insights and Guidelines.Cureus · 2024Review
- The dietary changes during Ramadan and their impact on anthropometry, blood pressure, and metabolic profile.Frontiers in nutrition · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe dramatic change in lifestyle associated with Ramadan fasting raises questions about its effect on metabolism and health. Metabolites, as the end product of metabolism, are excellent candidates to be studied in this regard.
objectiveThis study aims to investigate the effect of Ramadan fasting on the metabolic profile and risk of chronic diseases.
methodsThe London Ramadan study (LORANS) is an observational study in which 2 blood samples were collected from 72 participants a few days before and after the fasting month of Ramadan. We conducted metabolomic profiling using nuclear magnetic resonance spectroscopy to assess the change in individual metabolites from before to after Ramadan. Also, we generated metabolic scores (scaled from 0 to 100) for 7 chronic diseases in the UK Biobank and assessed the association of Ramadan fasting with these scores in LORANS.
resultsOf the 72 participants, 35 were male (48.6%); the mean (± standard deviation) age was 45.7 (±16) y. Ramadan fasting was associated with changes in 14 metabolites (1 inflammation marker, 1 amino acid, 2 glycolysis-related metabolites, 2 ketone bodies, 2 triglyceride, and 6 lipoprotein subclasses), independent of changes in body composition. Using data from 117,981 participants in the UK Biobank, we generated metabolic scores for diabetes, hypertension, coronary artery disease, renal failure, colorectal cancer, breast cancer, and lung cancer. The metabolic scores for lung cancer, colorectal cancer, and breast cancer were lower after Ramadan in LORANS (-4.74, 9.6%, 95% confidence interval -6.56, -2.91, P < 0.001), (-1.09, -2.4%, -1.69, -0. 50, P < 0.001), and (-0.48, -1.1%, -0. 81, -0.15, P = 0.006), respectively.
conclusionsRamadan fasting is associated with short-term favorable changes in the metabolic profile concerning risk of some chronic diseases. These findings should be further investigated in future, larger studies of longer follow-up with clinical outcomes.
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