Evidence map›Paper›PMID 38301747›Full record

Observational studyJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2024

IV Thrombolysis for central retinal artery occlusion - Real-world experience from a comprehensive stroke center.

Christoph Stretz, John E Paddock, Tina M Burton, Tatiana Bakaeva, Melissa Freeman, Aparna Choudhury, Shadi Yaghi, Karen L Furie, Matthew Schrag, Brian Mac Grory

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Effectiveness and safety of intravenous thrombolysis for non-arteritic central retinal artery occlusion: A GRADE-assessed meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christoph StretzDepartment of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, United States. Electronic address: christoph_stretz@brown.edu.
John E PaddockDepartment of Ophthalmology, Weill Cornell Medicine, Cornell University, New York, NY, United States; Department of Neurology, Weill Cornell Medicine, Cornell University, New York, NY, United States.
Tina M BurtonDepartment of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, United States.
Tatiana BakaevaDepartment of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, United States; Division of Ophthalmology, The Warren Alpert Medical School of Brown University, Providence, RI, United States.
Melissa FreemanDepartment of Neurology, Duke University School of Medicine, Durham, NC, United States.
Aparna ChoudhuryDepartment of Neurology, Duke University School of Medicine, Durham, NC, United States.
Shadi YaghiDepartment of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, United States.
Karen L FurieDepartment of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, United States.
Matthew SchragDepartment of Neurology, Vanderbilt University School of Medicine, Nashville, TN, United States.
Brian Mac GroryDepartment of Neurology, Duke University School of Medicine, Durham, NC, United States; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, United States.
Brown University · USDuke University · USCornell University · USVanderbilt University · US

Funding

Cardioembolism as a Mechanism of Central Retinal Artery OcclusionK23HL161426 · NHLBI · DUKE UNIVERSITY · PI Brian Mac Grory · 2022 to 2026
$951k
NHLBI NIH HHS K23 HL161426
6 · The paper itself

Abstract

objectivesCentral retinal artery occlusion (CRAO) is a stroke of the retina potentially amenable to intravenous thrombolysis (IVT). We aimed to determine feasibility of an emergency treatment protocol and risk profile of IVT for CRAO in a comprehensive stroke center (CSC).

methodsWe performed a retrospective, observational cohort study including patients with acute CRAO admitted to a CSC over 4 years. Patients are offered IVT if they present with acute vision loss of ≤ 20/200 in the affected eye, have no other cause of vision loss (incorporating a dilated ophthalmologic exam), and meet criteria akin to acute ischemic stroke. We collected socio-demographic data, triage data, time from onset to presentation, IVT candidacy, and rates of symptomatic intracranial hemorrhage (sICH)- or extracranial hemorrhage.

results36 patients presented within the study period, mean (standard deviation (SD)) age of 70.7 (10), 52 % female, and median time (Q1, Q3) to ED presentation of 13.5 (4.3, 18.8) h. Patients within 4.5 h from onset presented more commonly directly to our ED (66.6 % vs 37.1 %, p = 0.1). Nine patients (25 %) presented within the 4.5 h window. Of those eligible, 7 (77 %) received IVT. There were no events of intracranial or extracranial hemorrhage.

conclusionsOur study confirmed that IVT for acute CRAO is feasible. We found a high rate of treatment with IVT of those eligible. However, because 75 % of patients presented outside the treatment window, continued educational efforts are needed to improve rapid triage to emergency departments to facilitate evaluation for possible candidacy with IVT.

Indexed as

Brain IschemiaIschemic StrokeRetinal Artery OcclusionStrokeAgedAged, 80 and overFemaleFibrinolytic AgentsHumansIntracranial HemorrhagesMaleMiddle AgedRetrospective StudiesThrombolytic TherapyTreatment OutcomeFibrinolytic AgentsCentral retinal artery occlusionIschemic strokethrombolysisTreatment

Identifiers

PMID38301747
PMCPMC11145518
OpenAlexW4391364340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.