Evidence map›Paper›PMID 38301454›Full record

ArticleEpilepsy & behavior : E&B2024

Elevated phase amplitude coupling as a depression biomarker in epilepsy.

James J Young, Andy Ho Wing Chan, Nathalie Jette, Heidi A Bender, Adam E Saad, Ignacio Saez, Fedor Panov, Saadi Ghatan, Ji Yeoun Yoo, Anuradha Singh and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

James J YoungDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: james.young@mssm.edu.
Andy Ho Wing ChanDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: howing.chan@mountsinai.org.
Nathalie JetteDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: nathalie.jette@mssm.edu.
Heidi A BenderWeill Cornell Medicine, Department of Neurological Surgery, 525 East 68th Street, New York, NY 10021, USA.
Adam E SaadDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: adam.saad@mssm.edu.
Ignacio SaezDepartments of Neurocience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. Electronic address: ignacio.saez@mssm.edu.
Fedor PanovDepartments of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: fedor.panov@mountsinai.org.
Saadi GhatanDepartments of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: saadi.ghatan@mountsinai.org.
Ji Yeoun YooDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: jiyeoun.yoo@mssm.edu.
Anuradha SinghDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: anuradha.singh@mssm.edu.
Madeline C FieldsDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: madeline.fields@mssm.edu.
Lara V MarcuseDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: lara.marcuse@mssm.edu.
Helen S MaybergDepartments of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Departments of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. Electronic address: helen.mayberg@mssm.edu.
Icahn School of Medicine at Mount Sinai · USCircuit Therapeutics (United States) · USCornell University · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2017 to 2021
$21.7M
Mount Sinai Network of Excellence in Neuroscience Clinical TrialsU24NS107201 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JETTE, NATHALIE, MILLER, AARON · 2018 to 2022
$1.7M
NINDS NIH HHS U24 NS107201NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

Depression is prevalent in epilepsy patients and their intracranial brain activity recordings can be used to determine the types of brain activity that are associated with comorbid depression. We performed case-control comparison of spectral power and phase amplitude coupling (PAC) in 34 invasively monitored drug resistant epilepsy patients' brain recordings. The values of spectral power and PAC for one-minute segments out of every hour in a patient's study were correlated with pre-operative assessment of depressive symptoms by Beck Depression Inventory-II (BDI). We identified an elevated PAC signal (theta-alpha-beta phase (5-25 Hz)/gamma frequency (80-100 Hz) band) that is present in high BDI scores but not low BDI scores adult epilepsy patients in brain regions implicated in primary depression, including anterior cingulate cortex, amygdala and orbitofrontal cortex. Our results showed the application of PAC as a network-specific, electrophysiologic biomarker candidate for comorbid depression and its potential as treatment target for neuromodulation.

Indexed as

Brain WavesEpilepsyAdultBrainDepressionElectroencephalographyHumansPrefrontal CortexComorbid DepressionDepressionEpilepsyIntracranial EEGPhase Amplitude CouplingSpectral Power

Identifiers

PMID38301454
PMCPMC10923038
OpenAlexW4391426206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.