ArticleArchives of Iranian medicine2023
Complications and Related Risk Factors of Peripherally Inserted Central Catheters in Neonates: A Historical Cohort Study.
Article in Archives of Iranian medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 4 citations in OpenAlex.
- Incidence and risk factors for peripheral intravenous catheter failure in Japanese neonatal intensive care units and growing care units: a multicenter observational study.Fujita medical journal · 2026Article
- Abscess formation following secondary migration of peripherally inserted central catheter in a neonate: a case report and review of literature.International journal of surgery case reports · 2026Article
- Observational
- Development and validation of a machine learning-based risk prediction model for PICC-associated bloodstream infections in preterm infants: a retrospective multicenter study.Frontiers in pediatrics · 2026Article
- Primary malposition of peripherally inserted central catheter in the inferior vena cava among neonates: a case series.Frontiers in pediatrics · 2026Article
- Risk factors for peripherally inserted central catheter malposition in preterm infants: a multicenter retrospective study.Frontiers in pediatrics · 2025Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundPeripherally inserted central catheters (PICCs) are an effective method for medication and nutrition infusion in preterm neonates. The present study aimed to identify the incidence of the most common complications of PICC implantation and evaluate the risk factors of each complication.
methodsThis historical cohort study was conducted on 2500 neonates with birth weights (BWs)≥500 g and gestational age (GA)>24 weeks who had a history of PICC inserted in three NICUs between August 2015 and August 2018. Data were collected by reviewing medical records. Demographic data and indices of catheter placement, duration of catheter placement, and common complications were recorded. Data analysis was done using SPSS-21.
resultsThe median cubital vein had the most PICC placement (43%). The most common complication was tip malposition (48.2%). The incidence rates (95% CI) of the main complications such as malposition, edema/occlusion, and PICC migration were 0.0356 (0.0337-0.0377), 0.0134 (0.0122-0.0147), and 0.0088 (0.0079-0.0099), respectively. PICC insertion position was the strongest predictor of malposition for the cephalic vein. Besides, the incidence of malformation in the cephalic vein was about six times higher than in the median cubital vein. Independent risk factors for non-technical complications included BW (OR=0.59, 95% CI 0.44-0.79), administration of hyperosmolar medications (OR=3.43, 95% CI 2.62-4.51), position (OR=2.43, 95% CI 1.92- 3.08), and duration of catheter presence (OR=1.02, 95% CI 1.01-1.03) (
conclusionThe most common complication was malposition related to catheter placement in an emergency. Moreover, BW, administration of hyperosmolar medications, and duration of catheter presence were the most critical risk factors for non-technical complications. Therefore, it is recommended to educate the PICC insertion team to reduce tip malposition and replace long-term catheters.
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