Evidence map›Paper›PMID 38300944›Full record

ArticlePloS one2024

A pilot study using hospital surveillance and a birth cohort to investigate enteric pathogens and malnutrition in children, Dili, Timor-Leste.

Danielle M Cribb, Nevio Sarmento, Almerio Moniz, Nicholas S S Fancourt, Kathryn Glass, Anthony D K Draper, Joshua R Francis, Milena M Lay Dos Santos, Endang Soares da Silva, Benjamin G Polkinghorne and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Danielle M CribbNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID 0000-0002-7200-1227
Nevio SarmentoGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Almerio MonizNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.
Nicholas S S FancourtGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID 0000-0002-1772-9960
Kathryn GlassNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.
Anthony D K DraperNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.
Joshua R FrancisGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Milena M Lay Dos SantosTimor-Leste Ministry of Health, Dili, Timor-Leste.
Endang Soares da SilvaTimor-Leste Ministry of Health, Dili, Timor-Leste.
Benjamin G PolkinghorneNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID 0000-0002-6330-9588
Virginia de Lourdes da ConceiҫãoGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Feliciano da ConceiҫãoMinistry of Agriculture and Fisheries, Dili, Timor-Leste.
Paulino da SilvaGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Joanita JongMinistry of Agriculture and Fisheries, Dili, Timor-Leste.
Martyn D KirkNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID 0000-0001-5432-5984
Samantha ColquhounNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.
Australian National University · AUCharles Darwin University · AUUniversidade da Paz · TL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In low-to-middle-income countries (LMICs), enteric pathogens contribute to child malnutrition, affecting nutrient absorption, inducing inflammation, and causing diarrhoea. This is a substantial problem in LMICs due to high disease burden, poor sanitation and nutritional status, and the cyclical nature of pathogen infection and malnutrition. This relationship remains understudied in Timor-Leste. In our pilot study of enteric pathogens and malnutrition in Dili, Timor-Leste (July 2019-October 2020), we recruited 60 infants in a birth cohort from Hospital Nacional Guido Valadares (HNGV) with up to four home visits. We collected faecal samples and details of demographics, anthropometrics, diet and food practices, and animal husbandry. Additionally, we collected faecal samples, diagnostics, and anthropometrics from 160 children admitted to HNGV with a clinical diagnosis of severe diarrhoea or severe acute malnutrition (SAM). We tested faeces using the BioFire® FilmArray® Gastrointestinal Panel. We detected high prevalence of enteric pathogens in 68.8% (95%CI 60.4-76.2%) of infants at home, 88.6% of SAM cases (95%CI 81.7-93.3%) and 93.8% of severe diarrhoea cases (95%CI 67.7-99.7%). Diarrhoeagenic Escherichia coli and Campylobacter spp. were most frequently detected. Pathogen presence did not significantly differ in birth cohort diarrhoeal stool, but hospital data indicated associations between Salmonella and Shigella and diarrhoea. We observed wasting in 18.4% (95%CI 9.2-32.5%) to 30.8% (95%CI 17.5-47.7%) of infants across home visits, 57.9% (95%CI 34.0-78.9%) of severe diarrhoea cases, and 92.5% (95%CI 86.4-96.2%) of SAM cases. We associated bottle feeding with increased odds of pathogen detection when compared with exclusive breastfeeding at home (OR 8.3, 95%CI 1.1-62.7). We detected high prevalence of enteric pathogens and signs of malnutrition in children in Dili. Our pilot is proof of concept for a study to fully explore the risk factors and associations between enteric pathogens and malnutrition in Timor-Leste.

Indexed as

Child Nutrition DisordersMalnutritionSevere Acute MalnutritionAnimalsBirth CohortChildDiarrheaFemaleHospitalsHumansInfantPilot ProjectsTimor-Leste

Identifiers

PMID38300944
PMCPMC10833528
OpenAlexW4391428626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.