Evidence map›Paper›PMID 38300867›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Excess natural-cause mortality in US counties and its association with reported COVID-19 deaths.

Eugenio Paglino, Dielle J Lundberg, Elizabeth Wrigley-Field, Zhenwei Zhou, Joe A Wasserman, Rafeya Raquib, Yea-Hung Chen, Katherine Hempstead, Samuel H Preston, Irma T Elo and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Trends in maternal mortality rates by state, United States, 2018 to 2023.American journal of obstetrics and gynecology · 2026
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  19. Excess Mortality Estimation.Annual review of statistics and its application · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Eugenio PaglinoDepartment of Sociology and Population Studies Center, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-8733-6460
Dielle J LundbergDepartment of Global Health, Boston University School of Public Health, Boston, MA 02118.
Elizabeth Wrigley-FieldDepartment of Sociology and Minnesota Population Center, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0003-3489-4279
Zhenwei ZhouDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118.ORCID 0000-0002-9424-7826
Joe A WassermanResearch Triangle Institute, Research Triangle Park, NC 27709.ORCID 0000-0002-9705-1853
Rafeya RaquibDepartment of Global Health, Boston University School of Public Health, Boston, MA 02118.
Yea-Hung ChenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158.ORCID 0000-0002-7949-0692
Katherine HempsteadRobert Wood Johnson Foundation, Princeton, NJ 08540.
Samuel H PrestonDepartment of Sociology and Population Studies Center, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-7038-9689
Irma T EloDepartment of Sociology and Population Studies Center, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-1858-8239
M Maria GlymourDepartment of Epidemiology, Boston University School of Public Health, Boston, MA 02118.
Andrew C StokesDepartment of Global Health, Boston University School of Public Health, Boston, MA 02118.ORCID 0000-0002-8502-3636

Funding

University of Washington Health Services Research Training ProgramT32HS013853 · AHRQ · UNIVERSITY OF WASHINGTON · PI WEINER, BRYAN J., WILLIAMS, EMILY CATERINA · 2003 to 2024
$6.9M
Minnesota Population Center Science and Technical CoreP2CHD041023 · NICHD · UNIVERSITY OF MINNESOTA · PI THERESA LOUISE OSYPUK · 2016 to 2026
$4.3M
Spatial Analysis CoreR24HD041023 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI RUGGLES, STEVE · 2001 to 2016
$4.1M
Causes of Geographic Divergence in American Mortality Between 1990 and 2015: Health Behaviors, Health Care Access and MigrationR01AG060115 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ELO, IRMA T. · 2018 to 2022
$1.9M
Lifecourse Stressors and Social Disparities in Cognitive Aging: The Roles of Social Networks and Sleep DisturbanceK00AG068431 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, RUIJIA · 2021 to 2024
$330k
AHRQ HHS T32 HS013853NIA NIH HHS K00 AG068431NIA NIH HHS R01 AG060115NICHD NIH HHS P2C HD041023NICHD NIH HHS R24 HD041023
6 · The paper itself

Abstract

In the United States, estimates of excess deaths attributable to the COVID-19 pandemic have consistently surpassed reported COVID-19 death counts. Excess deaths reported to non-COVID-19 natural causes may represent unrecognized COVID-19 deaths, deaths caused by pandemic health care interruptions, and/or deaths from the pandemic's socioeconomic impacts. The geographic and temporal distribution of these deaths may help to evaluate which explanation is most plausible. We developed a Bayesian hierarchical model to produce monthly estimates of excess natural-cause mortality for US counties over the first 30 mo of the pandemic. From March 2020 through August 2022, 1,194,610 excess natural-cause deaths occurred nationally [90% PI (Posterior Interval): 1,046,000 to 1,340,204]. A total of 162,886 of these excess natural-cause deaths (90% PI: 14,276 to 308,480) were not reported to COVID-19. Overall, 15.8 excess deaths were reported to non-COVID-19 natural causes for every 100 reported COVID-19 deaths. This number was greater in nonmetropolitan counties (36.0 deaths), the West (Rocky Mountain states: 31.6 deaths; Pacific states: 25.5 deaths), and the South (East South Central states: 26.0 deaths; South Atlantic states: 25.0 deaths; West South Central states: 24.2 deaths). In contrast, reported COVID-19 death counts surpassed estimates of excess natural-cause deaths in metropolitan counties in the New England and Middle Atlantic states. Increases in reported COVID-19 deaths correlated temporally with increases in excess deaths reported to non-COVID-19 natural causes in the same and/or prior month. This suggests that many excess deaths reported to non-COVID-19 natural causes during the first 30 mo of the pandemic in the United States were unrecognized COVID-19 deaths.

Indexed as

COVID-19Bayes TheoremCause of DeathHumansMortalityNew EnglandPandemicsUnited StatesCOVID-19death investigation systemexcess mortalitygeographic inequitiesrural health

Identifiers

PMID38300867
PMCPMC10861891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.