Evidence map›Paper›PMID 38300339›Full record

ArticleJournal of molecular neuroscience : MN2024

Whole Blood Transcriptome Analysis in Patients with Trigeminal Neuralgia: a Prospective Clinical Study.

Tianyu Liu, Chao Xu, Jiaqi Guo, Zile He, Yunpeng Zhang, Yi Feng

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04923399 (Transcriptome Sequencing Analysis of Whole Blood From Patients With Trigeminal Neuralgia), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04923399 unknown statusnot on this map

Transcriptome Sequencing Analysis of Whole Blood From Patients With Trigeminal Neuralgia: An Observational Study

Typeobservational_patient_registrySponsorPeking University People's HospitalRan2021 to 2023Enrolled20ConditionsTrigeminal Neuralgia, Blood, Plasma, Cerebrospinal Fluid
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Tianyu Liu *Department of Anesthesiology, Peking University People's Hospital, Xizhimen South Street 11, Beijing, 100044, China.ORCID http://orcid.org/0000-0002-6769-5690
Chao Xu *Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-8000-106X
Jiaqi Guo *Shanghai Minhang Center for Disease Control and Prevention, Shanghai, China.ORCID http://orcid.org/0009-0009-9968-7714
Zile HeDepartment of Anesthesiology, Peking University People's Hospital, Xizhimen South Street 11, Beijing, 100044, China.ORCID http://orcid.org/0000-0002-3499-9022
Yunpeng ZhangDepartment of Anesthesiology, Peking University People's Hospital, Xizhimen South Street 11, Beijing, 100044, China.ORCID http://orcid.org/0000-0003-1552-2250
Yi FengDepartment of Anesthesiology, Peking University People's Hospital, Xizhimen South Street 11, Beijing, 100044, China. doctor_yifeng@sina.com.ORCID http://orcid.org/0000-0002-3952-1351
Peking University · CNShanghai Municipal Center For Disease Control Prevention · CNSun Yat-sen University · CN

Funding

National Key Research and Development Program of China No.2018YFC2001905
6 · The paper itself

Abstract

Trigeminal neuralgia (TN) brings a huge burden to patients, without long-term effective treatment. This study aimed to explore the differentially expressed genes (DEGs) and related enrichment pathways in patients with TN. This was a study of transcriptome sequencing and bioinformatics analysis of human samples. Whole blood samples were collected from the TN patients and pain-free controls. RNA was extracted to conduct the RNA-sequencing and the subsequent bioinformatics analysis. DEGs between the two groups were derived. Kyoto encyclopedia of genes and genomes (KEGG) and Gene ontology (GO) was used to find the enrichment pathways of DEGs. Protein protein interaction (PPI) network was used to depict the interaction between DEGs and find the most important gene, hub gene. Compared with the control group, there were 117 up-regulated DEGs and 103 down-regulated DEGs in the whole blood of patients in the TN group. Pathway enrichment analysis showed that DEGs were mainly enriched in the neuroimmune and metabolic pathways. The PPI network demonstrated that colony stimulating factor 2 (CSF2) was the most important hub gene in the whole blood of TN patients. This study shows the expression of the transcriptome in the whole blood samples of TN patients. The neuroimmune responses and key hub gene CSF2 in the whole blood cells play a vital role in the occurrence of TN. Our research provides a theoretical basis for the diagnosis and treatments of TN. This study was registered at clinicaltrials.gov in June 2021 (No. NCT04923399).

Indexed as

Trigeminal NeuralgiaGene Expression ProfilingHumansProspective StudiesRNATranscriptomeRNACSF2Neuroimmune responseRNA-seqTranscriptome analysisTrigeminal neuralgia

Identifiers

PMID38300339
OpenAlexW4391437119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.