Evidence map›Paper›PMID 38299867›Full record

Trial reportMicrobiology spectrum2024

Respiratory virus coinfections during the COVID-19 pandemic: epidemiologic analysis and clinical outcomes from the Phase 2/3 molnupiravir trial (MOVe-OUT).

Matthew G Johnson, Julie M Strizki, Erin Jensen, Jonathan Cohen, Christine Katlama, Roman Fishchuk, Alfredo Ponce-de-León, Nyda Fourie, Chien-Yu Cheng, Dorothy McCoy and 9 more

Open access · goldAbstract readClinical Trial, Phase IIIClinical Trial, Phase II
In one paragraph

Trial report in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 5 countries.

Matthew G JohnsonMerck & Co., Inc., Rahway, New Jersey, USA.ORCID 0000-0002-6023-1252
Julie M StrizkiMerck & Co., Inc., Rahway, New Jersey, USA.ORCID 0009-0002-3893-9374
Erin JensenMerck & Co., Inc., Rahway, New Jersey, USA.
Jonathan CohenJadestone Clinical Research, LLC, Rockville, Maryland, USA.
Christine KatlamaAP-HP. Sorbonne Université, Hôpital-Pitié Salpêtrière, Paris, France.ORCID 0000-0002-5093-4800
Roman FishchukCNE Central City Clinical Hospital of Ivano-Frankivsk City Council, Ivano-Frankivsk, Ukraine.
Alfredo Ponce-de-LeónInstituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran, Mexico City, Mexico.ORCID 0000-0003-2640-2916
Nyda FourieIATROS International, Bloemfontein, South Africa.
Chien-Yu ChengTaoyuan General Hospital, Taoyuan, Taiwan.ORCID 0000-0002-1886-0370
Dorothy McCoyMerck & Co., Inc., Rahway, New Jersey, USA.ORCID 0009-0008-9130-462X
Mary VesneskyMerck & Co., Inc., Rahway, New Jersey, USA.
Carmelle T NoriceMerck & Co., Inc., Rahway, New Jersey, USA.
Ying ZhangMerck & Co., Inc., Rahway, New Jersey, USA.
Angela Williams-DiazMerck & Co., Inc., Rahway, New Jersey, USA.
Michelle L BrownMerck & Co., Inc., Rahway, New Jersey, USA.
Patricia CarmelitanoMerck & Co., Inc., Rahway, New Jersey, USA.
Jay A GroblerMerck & Co., Inc., Rahway, New Jersey, USA.
Amanda PaschkeMerck & Co., Inc., Rahway, New Jersey, USA.
Carisa De AndaMerck & Co., Inc., Rahway, New Jersey, USA.
Merck & Co., Inc., Rahway, NJ, USA (United States) · USInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXIvano-Frankivsk National Medical University · UATao Yuan General Hospital · TWUniversité Toulouse III - Paul Sabatier · FR

Funding

Merck (Merck & Co.)
6 · The paper itself

Abstract

This exploratory IMPORTANCE: Respiratory viral coinfections are known to occur with coronavirus disease-2019 (COVID-19). In a cohort of non-hospitalized adults with mild-to-moderate COVID-19 treated with molnupiravir versus placebo in the MOVe-OUT trial during October 2020 to October 2021, 4.1% of participants had a documented viral coinfection; human rhinovirus/enterovirus was the most common pathogen detected with the NxTAG Respiratory Pathogen Panel assay. Participants who had a coinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and another respiratory RNA virus were not more likely to have worse clinical outcomes compared to those participants without a viral coinfection, and many coinfecting respiratory RNA viruses were no longer detected at the end of the 5-day treatment period in both groups.

Indexed as

CoinfectionCOVID-19HydroxylaminesAdultCytidineHumansPandemicsRNASARS-CoV-2CytidineHydroxylaminesmolnupiravirRNACOVID-19epidemiologymolnupiravirrespiratory pathogens

Identifiers

PMID38299867
PMCPMC10913477
OpenAlexW4391434610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.