Evidence map›Paper›PMID 38299826›Full record

ArticleInfection and immunity2024

Mast cell-derived IL-10 protects intestinal barrier integrity during malaria in mice and regulates parasite transmission to

Nora Céspedes, Erinn L Donnelly, Gretchen Hansten, Abigail M Fellows, Megan Dobson, Hannah L Kaylor, Taylor A Coles, Joseph Schauer, Judy Van de Water, Shirley Luckhart

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nora CéspedesDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, Idaho, USA.ORCID 0009-0006-0626-1393
Erinn L DonnellyDepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USA.
Gretchen HanstenDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, Idaho, USA.
Abigail M FellowsDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, Idaho, USA.
Megan DobsonDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, Idaho, USA.
Hannah L KaylorDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, Idaho, USA.
Taylor A ColesDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, Idaho, USA.
Joseph SchauerDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, California, USA.
Judy Van de WaterDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, California, USA.
Shirley LuckhartDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0001-5047-4683
University of Idaho · USUniversity of California, Davis · US

Funding

Biogenic amines, malaria and manipulation of mosquito physiology and behavior.R01AI165481 · NIAID · UNIVERSITY OF IDAHO · PI LUCKHART, SHIRLEY, RIFFELL, JEFFREY A · 2022 to 2025
$2.2M
Malaria and allergic inflammatory changes to the gut barrierR01AI131609 · NIAID · UNIVERSITY OF IDAHO · PI LUCKHART, SHIRLEY · 2018 to 2021
$1.9M
NIAID NIH HHS R01 AI131609NIAID NIH HHS R01 AI165481
6 · The paper itself

Abstract

Malaria is strongly predisposed to bacteremia, which is associated with increased gastrointestinal permeability and a poor clinical prognosis. We previously identified mast cells (MCs) as mediators of intestinal permeability in malaria and described multiple cytokines that rise with parasitemia, including interleukin (IL)-10, which could protect the host from an inflammatory response and alter parasite transmission to

Indexed as

AnophelesMalariaParasitesPlasmodium yoeliiAnimalsChemokinesCytokinesFemaleImmunityInterleukin-10MaleMast CellsMiceParasitemiaChemokinesCytokinesInterleukin-10Anophelesbacteremiainterleukin 10malariamast cellstransmission

Identifiers

PMID38299826
PMCPMC10929420
OpenAlexW4391449832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.