Evidence map›Paper›PMID 38299395›Full record

ArticleCurrent medicinal chemistry2024

High-expression of FABP4 in Tubules is a Risk Factor for Poor Prognosis in DKD Patients.

Yao Huang, Xinyuan Cui, Zheng Li, Shuguang Yuan, Yachun Han, Xiangqing Xu, Xiao Fu, Kewen Shi, Zurong Zhang, Jinying Wei and 6 more

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Article in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Yao HuangDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xinyuan CuiDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Zheng LiDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Shuguang YuanDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yachun HanDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiangqing XuDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiao FuDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Kewen ShiDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Zurong ZhangDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jinying WeiDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Shiyu XiaDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yang XiaoKey Laboratory of Diabetes Immunology, Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Ministry of Education, The Second Xiangya Hospital of Central South University, Changsha, China.
Song XueKey Laboratory of Diabetes Immunology, Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Ministry of Education, The Second Xiangya Hospital of Central South University, Changsha, China.
Lin SunDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Hong LiuDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xuejing ZhuDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Soil and Fertilizer Institute of Hunan Province · CNCentral South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

General Project of Scientific Research Project of Hunan Provincial Health and Family Planning Commission 20200807Hunan Provincial Natural Science Foundation of China 2021JJ30986, 2018JJ3728National Natural Science Foundation of China 81300600, 81730018
6 · The paper itself

Abstract

backgroundLipid metabolism imbalance is involved in the mechanism of renal tubular injury in diabetic kidney disease (DKD). Fatty acid binding protein 4 (FABP4) has been reported to participate in cellular lipid toxicity. However, the expression of FABP4 in renal tissues of DKD and its correlation with clinical/ pathological parameters and prognosis have not been studied.

methodsA retrospective cohort study was conducted in 108 hospitalized Type 2 diabetes (T2D) patients with renal injury, including 70 with DKD and 38 with NDKD (non-DKD). Clinical features, pathological findings, and follow-up parameters were collected. Serum and urine FABP4 were detected by ELISA. An immunohistochemistry stain was used to determine FABP4 in renal tubulointerstitium. A double immunofluorescence stain was employed to assess FABP4- and CD68-positive macrophages. Correlation analysis, logistic regression models, receiver operating characteristic (ROC), and Kaplan-Meier survival curve were performed for statistical analysis.

resultsDKD patients had increased expression of FABP4 and ectopic fat deposition in tubules. As shown by correlation analyses, FABP4 expression in renal tubules was positively correlated with UNAG (r=0.589, p=0.044) and ESRD (r=0.740, p=0.004). Multivariate regression analysis revealed that UNAG level was correlated with FABP4 expression level above median value (odds ratio:1.154, 95% confidence interval:1.009-1.321, p=0.037). High-expression of FABP4 in renal tubules of DKD was at an increased risk of ESRD. Increased FABP4 expression in inflammatory cells was also associated with ESRD in DKD.

conclusionHigh-expression of FABP4 is involved in the pathogenesis of renal tubular lipid injury and is a risk factor for poor prognosis in DKD patients.

Indexed as

Diabetic NephropathiesFatty Acid-Binding ProteinsKidney TubulesAgedDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsFABP4 protein, humanFatty Acid-Binding ProteinsDiabetic kidney diseaseendoplasmic reticulumfatty acid binding protein 4obesityrenal tubular injuryrenal tubules.

Identifiers

PMID38299395
OpenAlexW4391447573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.