Evidence map›Paper›PMID 38299343›Full record

ArticlemAbs

Jing Song, Marc Taraban, Y Bruce Yu, Lynn Lu, Pallavi Guha Biswas, Wei Xu, Hanmi Xi, Akhilesh Bhambhani, Guangli Hu, Yongchao Su

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jing SongAnalytical Research and Development, Merck & Co., Inc, Rahway, NJ, USA.
Marc TarabanUniversity of Maryland School of Pharmacy and Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.
Y Bruce YuUniversity of Maryland School of Pharmacy and Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.
Lynn LuPharmaceutical Sciences and Clinical Supply, Merck & Co., Inc, Rahway, NJ, USA.
Pallavi Guha BiswasUniversity of Maryland School of Pharmacy and Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.
Wei XuAnalytical Research and Development, Merck & Co., Inc, Rahway, NJ, USA.
Hanmi XiAnalytical Research and Development, Merck & Co., Inc, Rahway, NJ, USA.
Akhilesh BhambhaniPharmaceutical Sciences and Clinical Supply, Merck & Co., Inc, Rahway, NJ, USA.
Guangli HuPharmaceutical Sciences and Clinical Supply, Merck & Co., Inc, Rahway, NJ, USA.
Yongchao SuAnalytical Research and Development, Merck & Co., Inc, Rahway, NJ, USA.ORCID 0000-0001-5063-3218
Merck & Co., Inc., Rahway, NJ, USA (United States) · USResearch Institute for Bioscience and Biotechnology · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-concentration protein formulation is of paramount importance in patient-centric drug product development, but it also presents challenges due to the potential for enhanced aggregation and increased viscosity. The analysis of critical quality attributes often necessitates the transfer of samples from their primary containers together with sample dilution. Therefore, there is a demand for noninvasive,

Indexed as

Drug IndustryMagnetic Resonance SpectroscopyViscosityWaterWaterAccelerated stressbiologicsdrug product stabilityhigh-concentration drug productmABsNMRprotein aggregationwNMR

Identifiers

PMID38299343
PMCPMC10841025
OpenAlexW4391447592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.