Evidence map›Paper›PMID 38298829›Full record

ArticleThe World Allergy Organization journal2024

Atopic dermatitis-associated genetic variants regulate LOC100294145 expression implicating interleukin-27 production and type 1 interferon signaling.

Wei Yi Teo, Yi Ying Eliza Lim, Yang Yie Sio, Yee-How Say, Kavita Reginald, Fook Tim Chew

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Wei Yi TeoDepartment of Biological Sciences, National University of Singapore, Singapore.
Yi Ying Eliza LimDepartment of Biological Sciences, National University of Singapore, Singapore.
Yang Yie SioDepartment of Biological Sciences, National University of Singapore, Singapore.
Yee-How SayDepartment of Biological Sciences, National University of Singapore, Singapore.
Kavita ReginaldDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, Malaysia.
Fook Tim ChewDepartment of Biological Sciences, National University of Singapore, Singapore.
National University of Singapore · SGSunway University · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atopic dermatitis (AD) is a complex inflammatory disease with a strong genetic component. A singular approach of genome wide association studies (GWAS) can identify AD-associated genetic variants, but is unable to explain their functional relevance in AD. This study aims to characterize AD-associated genetic variants and elucidate the mechanisms leading to AD through a multi-omics approach. Methods: GWAS identified an association between genetic variants at 6p21.32 locus and AD. Genotypes of 6p21.32 locus variants were evaluated against Results: Minor alleles of rs116160149 and rs115388857 at 6p21.32 locus were associated with increased AD risk ( Conclusion: Genetic variants at 6p21.32 locus increase AD susceptibility through raising

Indexed as

Atopic dermatitisGenome-wide association studyLong non-coding RNAMendelian randomizationMulti-omics

Identifiers

PMID38298829
PMCPMC10827559
OpenAlexW4390825470

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.