Evidence map›Paper›PMID 38298781›Full record

ArticleBiological psychiatry global open science2024

Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium.

Benjamin Suarez-Jimenez, Amit Lazarov, Xi Zhu, Sigal Zilcha-Mano, Yoojean Kim, Claire E Marino, Pavel Rjabtsenkov, Shreya Y Bavdekar, Daniel S Pine, Yair Bar-Haim and 30 more

Erratum issuedAbstract read
In one paragraph

Article in Biological psychiatry global open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

40 authors.

Benjamin Suarez-JimenezDel Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Amit LazarovDepartment of Clinical Psychology, School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Xi ZhuDepartment of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York, New York.
Sigal Zilcha-ManoDepartment of Psychology, University of Haifa, Mount Carmel, Haifa, Israel.
Yoojean KimDepartment of Psychiatry, New York State Psychiatric Institute, New York, New York.
Claire E MarinoDel Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Pavel RjabtsenkovDel Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Shreya Y BavdekarDel Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Daniel S PineSection on Developmental Affective Neuroscience, National Institute of Mental Health, Bethesda, Maryland.
Yair Bar-HaimDepartment of Clinical Psychology, School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Christine L LarsonUniversity of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Ashley A HugginsDuke University, Durham, North Carolina.
Terri deRoon-CassiniMedical College of Wisconsin, Milwaukee, Wisconsin.
Carissa TomasMedical College of Wisconsin, Milwaukee, Wisconsin.
Jacklynn FitzgeraldMarquette University, Milwaukee, Wisconsin.
Mitzy KennisBrain Research and Innovation Centre, Ministry of Defence, Utrecht, the Netherlands.
Tim VarkevisserBrain Research and Innovation Centre, Ministry of Defence, Utrecht, the Netherlands.
Elbert GeuzeBrain Research and Innovation Centre, Ministry of Defence, Utrecht, the Netherlands.
Yann QuidéSchool of Psychology, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Wissam El HageUnité Mixte de Recherche 1253, Institut National de la Santé et de la Recherche Médicale, Université de Tours, Tours, France.
Xin WangUniversity of Toledo, Toledo, Ohio.
Erin N O'LearyUniversity of Toledo, Toledo, Ohio.
Andrew S CottonUniversity of Toledo, Toledo, Ohio.
Hong XieUniversity of Toledo, Toledo, Ohio.
Chiahao ShihUniversity of Toledo, Toledo, Ohio.
Seth G DisnerMinneapolis VA Health Care System, Minneapolis, Minnesota.
Nicholas D DavenportMinneapolis VA Health Care System, Minneapolis, Minnesota.
Scott R SponheimMinneapolis VA Health Care System, Minneapolis, Minnesota.
Saskia B J KochCentre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, the Netherlands.
Jessie L FrijlingDepartment of Psychiatry, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
Laura NawijnDepartment of Psychiatry, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
Mirjam van ZuidenDepartment of Psychiatry, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
Miranda OlffDepartment of Psychiatry, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Evan M GordonDepartment of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Geoffery MayVISN 17 Center of Excellence for Research on Returning War Veterans, U.S. Department of Veterans Affairs, Waco, Texas.
Steven M NelsonDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Meilin Jia-RichardsDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas.
Yuval NeriaDepartment of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York, New York.
Rajendra A MoreyDuke University, Durham, North Carolina.

Funding

Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI MICHELE RUCCI · 1985 to 2026
$17.5M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Study of early brain alterations that predict development of chronic PTSDR01MH110483 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WANG, XIN · 2016 to 2021
$3.8M
Acute Neurocognitive-affective Predictors of Chronic Post-trauma OutcomesR01MH106574 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI LARSON, CHRISTINE L · 2015 to 2019
$3.1M
Using novel virtual reality tasks to identify neural mechanisms of discrimination learning in PTSDR01MH131532 · NIMH · UNIVERSITY OF ROCHESTER · PI Benjamin Suarez-Jimenez · 2023 to 2026
$2.7M
Neural Signature of Fear Overgeneralization in Trauma Exposed AdultsR01MH105355 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI NERIA, YUVAL Y · 2015 to 2018
$1.7M
Neural Correlates of Location-Specific Contextual Threat Discrimination in Post-Traumatic Stress Disorders REV1K01MH118428 · NIMH · UNIVERSITY OF ROCHESTER · PI SUAREZ-JIMENEZ, BENJAMIN · 2018 to 2022
$807k
Identification of Distinct Multimodal Biotypes of PTSD Using Data Driven Approach: A Multisite Big Data StudyK01MH122774 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI ZHU, XI · 2021 to 2024
$705k
Longitudinal MRI study of PTSD development from days to weeks after traumaR21MH098198 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WANG, XIN · 2013 to 2014
$425k
A large sample machine learning network analysis of vertex cortical thickness measures for high resolution definition of PTSD related cortical structure abnormalitiesR21MH125277 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WANG, XIN · 2022 to 2023
$412k
Neuroimaging-based identification of Traumatic Brain Injury subtypesIK2CX001680 · VA · OLIN TEAGUE VETERANS CENTER · PI GORDON, EVAN M. · 2019 to 2021
–
CSRD VA IK2 CX001680Intramural NIH HHS ZIA MH002782NEI NIH HHS P30 EY001319NIMH NIH HHS K01 MH118428NIMH NIH HHS K01 MH122774NIMH NIH HHS R01 MH105355NIMH NIH HHS R01 MH106574NIMH NIH HHS R01 MH110483NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH131532NIMH NIH HHS R21 MH098198NIMH NIH HHS R21 MH125277RRD VA I01 RX000622RRD VA IK1 RX002325RRD VA IK2 RX000709RRD VA IK2 RX002922
6 · The paper itself

Abstract

Background: Intrusive traumatic re-experiencing domain (ITRED) was recently introduced as a novel perspective on posttraumatic psychopathology, proposing to focus research of posttraumatic stress disorder (PTSD) on the unique symptoms of intrusive and involuntary re-experiencing of the trauma, namely, intrusive memories, nightmares, and flashbacks. The aim of the present study was to explore ITRED from a neural network connectivity perspective. Methods: Data were collected from 9 sites taking part in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) PTSD Consortium ( Results: rsFC signatures differentiated TE-only participants from PTSD and ITRED-only participants at about 60% accuracy. Conversely, rsFC signatures did not differentiate PTSD from ITRED-only individuals (45% accuracy). Common features differentiating TE-only participants from PTSD and ITRED-only participants mainly involved default mode network-related pathways. Some unique features, such as connectivity within the frontoparietal network, differentiated TE-only participants from one group (PTSD or ITRED-only) but to a lesser extent from the other group. Conclusions: Neural network connectivity supports ITRED as a novel neurobiologically based approach to classifying posttrauma psychopathology.

Indexed as

ITREDMachine learningPTSDRe-experiencingResting-state functional connectivityTrauma exposure

Identifiers

PMID38298781
PMCPMC10829610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.