Evidence map›Paper›PMID 38298699›Full record

ArticleHeliyon2024

Modification patterns and metabolic characteristics of m

Bing He, Yiyang Hu, Hui Chen, Xia Xie, Chunli Gong, Zhibin Li, Yang Chen, Yufeng Xiao, Shiming Yang

Abstract read
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bing HeDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Yiyang HuDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Hui ChenDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Xia XieDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Chunli GongDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Zhibin LiDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Yang ChenDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Yufeng XiaoDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Shiming YangDepartment of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

M6A is essential for tumor occurrence and progression. The expression patterns of m6A regulators differ in various kinds of tumors. Transcriptomic expression statistics together with clinical data from a database were analyzed to distinguish patients with digestive tract tumors. Based on the expression patterns of diverse m6A regulators, patients were divided into several clusters. Survival analysis suggested significant differences in patient prognosis among the m6A clusters. The results showed overlapping of m6A expression patterns with energy metabolism and nucleotide metabolism. Functional analyses imply that m6A modifications in tumor cells probably drive metabolic reprogramming to sustain rapid proliferation of cancer cells. Our analysis highlights the m6A risk characterizes various kinds of metabolic features and predicts chemotherapy sensitivity in digestive tract tumors, providing evidence for m6A regulators as markers to predict patient outcomes.

Indexed as

DigestiveEpigeneticsm6AMetabolismTumor

Identifiers

PMID38298699
PMCPMC10828661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.