Evidence map›Paper›PMID 38298598›Full record

ArticleNanoscale advances2024

Comprehensive characterization of polyproline tri-helix macrocyclic nanoscaffolds for predictive ligand positioning.

Chia-Lung Tsai, Je-Wei Chang, Kum-Yi Cheng, Yu-Jing Lan, Yi-Cheng Hsu, Qun-Da Lin, Tzu-Yuan Chen, Orion Shih, Chih-Hsun Lin, Po-Hsun Chiang and 6 more

Abstract read
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In one paragraph

Article in Nanoscale advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chia-Lung TsaiDepartment of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.
Je-Wei ChangNational Synchrotron Radiation Research Center Hsinchu 300092 Taiwan usjeng@nsrrc.org.tw.
Kum-Yi ChengDepartment of Chemistry and Centre for Emerging Materials and Advanced Devices, National Taiwan University Taipei 106319 Taiwan chhchen@ntu.edu.tw.
Yu-Jing LanDepartment of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.ORCID https://orcid.org/0000-0002-5971-5284
Yi-Cheng HsuDepartment of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.
Qun-Da LinDepartment of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.
Tzu-Yuan ChenDepartment of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.
Orion ShihNational Synchrotron Radiation Research Center Hsinchu 300092 Taiwan usjeng@nsrrc.org.tw.
Chih-Hsun LinDepartment of Chemistry and Centre for Emerging Materials and Advanced Devices, National Taiwan University Taipei 106319 Taiwan chhchen@ntu.edu.tw.
Po-Hsun ChiangDepartment of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.
Mantas SimenasFaculty of Physics, Vilnius University Sauletekio 3 LT-10257 Vilnius Lithuania.ORCID https://orcid.org/0000-0002-2733-2270
Vidmantas KalendraFaculty of Physics, Vilnius University Sauletekio 3 LT-10257 Vilnius Lithuania.
Yun-Wei ChiangDepartment of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.ORCID https://orcid.org/0000-0002-2101-8918
Chun-Hsien ChenDepartment of Chemistry and Centre for Emerging Materials and Advanced Devices, National Taiwan University Taipei 106319 Taiwan chhchen@ntu.edu.tw.ORCID https://orcid.org/0000-0001-5507-3248
U-Ser JengNational Synchrotron Radiation Research Center Hsinchu 300092 Taiwan usjeng@nsrrc.org.tw.ORCID https://orcid.org/0000-0002-2247-5061
Sheng-Kai WangDepartment of Chemistry, National Tsing Hua University Hsinchu 300044 Taiwan skwang@mx.nthu.edu.tw ywchiang@mx.nthu.edu.tw.ORCID https://orcid.org/0000-0002-3827-7983

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multivalent ligands hold promise for enhancing avidity and selectivity to simultaneously target multimeric proteins, as well as potentially modulating receptor signaling in pharmaceutical applications. Essential for these manipulations are nanosized scaffolds that precisely control ligand display patterns, which can be achieved by using polyproline oligo-helix macrocyclic nanoscaffolds

Identifiers

PMID38298598
PMCPMC10825903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.