Evidence map›Paper›PMID 38298456›Full record

ArticleCerebral circulation - cognition and behavior2024

Standing middle cerebral artery velocity predicts cognitive function and gait speed in older adults with cognitive impairment, and is impacted by sex differences.

Laura K Fitzgibbon-Collins, Geoff B Coombs, Mamiko Noguchi, Shashankdhwaj Parihar, Richard L Hughson, Michael Borrie, Sue Peters, J Kevin Shoemaker, Jaspreet Bhangu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura K Fitzgibbon-CollinsDepartment of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, 1151 Richmond St, London, Ontario N6A 5C1, Canada.
Geoff B CoombsDepartment of Kinesiology, University of Western Ontario, 1151 Richmond St, London, Ontario N6A 3K7, Canada.
Mamiko NoguchiDepartment of Kinesiology, University of Waterloo, 200 University Ave W., Waterloo, Ontario N2L 3G1, Canada.
Shashankdhwaj PariharCognitive Clinical Research Group, Parkwood Institute, 550 Wellington Rd., London, Ontario N6C 0A7, Canada.
Richard L HughsonSchlegel-University of Waterloo Research Institute for Aging, University of Waterloo, 250 Laurelwood Dr., Waterloo, Ontario N2J 0E2, Canada.
Michael BorrieDepartment of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, 1151 Richmond St, London, Ontario N6A 5C1, Canada.
Sue PetersSchool of Physical Therapy, University of Western Ontario, 1151 Richmond St, London, Ontario N6A 3K7, Canada.
J Kevin ShoemakerDepartment of Kinesiology, University of Western Ontario, 1151 Richmond St, London, Ontario N6A 3K7, Canada.
Jaspreet BhanguDepartment of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, 1151 Richmond St, London, Ontario N6A 5C1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upright posture challenges the cerebrovascular system, leading to changes in middle cerebral artery velocity (MCAv) dynamics which are less evident at supine rest. Chronic alterations in MCAv have been linked to hypoperfusion states and the effect that this may have on cognition remains unclear. This study aimed to determine if MCAv and oscillatory metrics of MCAv (ex. pulsatility index, PI) during upright posture are i) associated with cognitive function and gait speed (GS) to a greater extent than during supine rest, and ii) are different between sexes. Beat-by-beat MCAv (transcranial Doppler ultrasound) and mean arterial pressure (MAP, plethysmography) were averaged for 30-seconds during supine-rest through a transition to standing for 53 participants (73±6yrs, 17 females). While controlling for age, multiple linear regressions predicting MoCA scores and GS from age, supine MCAv metrics, and standing MCAv metrics, were completed. Simple linear regressions predicting Montreal Cognitive Assessment (MoCA) score and GS from MCAv metrics were performed separately for females and males. Significance was set to

Indexed as

Cerebral perfusionMontreal cognitive assessmentPulsatility indexSex differencesSupine to standTranscranial doppler

Identifiers

PMID38298456
PMCPMC10827680

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.