Evidence map›Paper›PMID 38298159›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Altered cerebellar and caudate gray-matter volumes and structural covariance networks preceding dual cognitive and mobility impairments in older people.

Pei-Lin Lee, Kun-Hsien Chou, Wei-Ju Lee, Li-Ning Peng, Liang-Kung Chen, Ching-Po Lin, Chih-Kuang Liang, Chih-Ping Chung

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Pei-Lin LeeCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Kun-Hsien ChouInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wei-Ju LeeCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Li-Ning PengCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Liang-Kung ChenCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ching-Po LinInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chih-Kuang LiangCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0003-1604-1600
Chih-Ping ChungCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0001-9419-9070
National Yang Ming Chiao Tung University · TW

Funding

Center for Geriatrics and GerontologyCenter for Healthy Longevity and Aging SciencesMinistry of Science and Technology, Taiwan 111VACS-001Ministry of Science and Technology, Taiwan NSTC 112-2321-B-075-004Ministry of Science and Technology, Taiwan NSTC 112-2321-B-A49-008Ministry of Science and Technology, Taiwan YSVH11002National Yang Ming UniversityTaipei Veterans General Hospital, Taipei, Taiwan
6 · The paper itself

Abstract

introductionThe neuroanatomical changes driving both cognitive and mobility impairments, an emerging preclinical dementia syndrome, are not fully understood. We examined gray-matter volumes (GMVs) and structural covariance networks (SCNs) abnormalities in community-based older people preceding the conversion to physio-cognitive decline syndrome (PCDS).

methodsVoxel-wise brain GMV and established SCNs were compared between PCDS and non-PCDS converters.

resultsThe study included 343 individuals (60.2 ± 6.9 years, 49.6% men) with intact cognitive and mobility functions. Over an average 5.6-year follow-up, 116 transitioned to PCDS. Identified regions with abnormal GMVs in PCDS converters were over cerebellum and caudate, which served as seeds for SCNs establishment. Significant differences in cerebellum-based (to right frontal pole and left middle frontal gyrus) and caudate-based SCNs (to right caudate putamen, right planum temporale, left precentral gyrus, right postcentral gyrus, and left parietal operculum) between converters and nonconverters were observed. DISCUSSION: This study reveals early neuroanatomic changes, emphasizing the cerebellum's role, in dual cognitive and mobility impairments. HIGHLIGHTS: Neuroanatomic precursors of dual cognitive and mobility impairments are identified. Cerebellar GMV reductions and increased right caudate GMV precede the onset of PCDS. Altered cerebellum- and caudate-based SCNs drive PCDS transformation. This research establishes a foundation for understanding PCDS as a specific dementia syndrome.

Indexed as

DementiaMagnetic Resonance ImagingAgedBrainCerebellumCognitionFemaleGray MatterHumansMalecaudatecerebello‐frontal networkcerebellum crus IIcerebellum VIIIDiagnostic and Statistical Manual of Mental Disorders ‐ III‐ revised version (DSM‐III‐R)dual cognitive and mobility declinegray‐matter volumephysio‐cognitive decline syndromestructural covariancesubcortical network

Identifiers

PMID38298159
PMCPMC11032519
OpenAlexW4391446778

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.