ArticleBJPsych open2024
Depression, anxiety and brain volume after hearing loss and tinnitus: cohort study in the UK Biobank.
Article in BJPsych open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Alzheimer's disease biomarkers in relation to non-cognitive domains within the intrinsic capacity framework: a narrative review.GeroScience · 2026Review
- Sensory impairment and risk of incident depression in older adults: a harmonized longitudinal analysis of 72,177 individuals across six international cohorts.Frontiers in public health · 2026Article
- The mediating effect of depression on the association of hearing loss with all-cause and cardiovascular mortality: a prospective cohort study.BMC public health · 2025Article
- Increased basal ganglia volume in older adults with tinnitus.Scientific reports · 2025Article
- Identification of Risk Loci for Radiotherapy-Induced Tinnitus and Hearing Loss Through Integrated Genomic Analysis.International journal of molecular sciences · 2025Article
- Distinct changes in the morphology of cortical and subcortical grey matter associated with age-related hearing loss and tinnitus in the UK Biobank participants.Brain communications · 2025Article
- Topic modeling and content analysis of people's anxiety-related concerns raised on a computer-mediated health platform.Scientific reports · 2024Article
- Association of oxidative balance score with hearing loss and tinnitus: NHANES 1999-2018.Frontiers in nutrition · 2024Article
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Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHearing loss and tinnitus have been proposed as potential indicators of impaired mental health and brain morphological changes.
aimsTo assess the associations of hearing loss and tinnitus with the risk of depression and anxiety and with brain volume.
methodWe conducted a community-based cohort study including 129 610 participants aged 40-69 years at recruitment to the UK Biobank with a follow-up period during 2006-2021 to estimate the risk of depression and anxiety after detection of hearing loss and reported tinnitus. We also assessed the associations of hearing loss and tinnitus with brain volume in a subsample with available brain magnetic resonance imaging data (
resultsWe observed an increased risk of depression among individuals with hearing loss (hazard ratio [HR] 1.14, 95% CI 1.03-1.26), tinnitus (HR 1.30, 95% CI 1.21-1.41) or both (HR 1.32, 95% CI 1.15-1.52), compared with individuals with neither hearing loss nor tinnitus. Similar results were noted for anxiety (HR 1.18, 95% CI 1.07-1.30 for hearing loss; HR 1.32, 95% CI 1.22-1.43 for tinnitus; and HR 1.48, 95% CI 1.30-1.68 for both). Hearing loss was associated with decreased overall brain volume as well as decreased volume of different brain regions. The latter associations disappeared after adjustment for whole intracranial volume. Tinnitus was associated with greater left accumbens and right occipital pole volume after adjustment for the whole intracranial volume.
conclusionsIndividuals with tinnitus are at increased risk of depression and anxiety. Hearing loss, on the other hand, is associated with both mood disorders and altered brain morphology.
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