Evidence map›Paper›PMID 38297839›Full record

ArticlePlant communications2024

Two aquaporins, PIP1;1 and PIP2;1, mediate the uptake of neonicotinoid pesticides in plants.

Qun Wan, Yixin Li, Jinjin Cheng, Ya Wang, Jing Ge, Tingli Liu, Liya Ma, Yong Li, Jianan Liu, Chunli Zhou and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Qun WanKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Yixin LiInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Jinjin ChengKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Ya WangKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Jing GeKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Tingli LiuJiangsu Provincial Key Construction Laboratory of Special Biomass Resource Utilization, Nanjing Xiaozhuang University, 3601 Hongjin Avenue, Nanjing 211171, China.
Liya MaKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Yong LiKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Jianan LiuInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Chunli ZhouInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Haocong LiInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Xing SunKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Xiaolong ChenKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China.
Qing X LiDepartment of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Xiangyang YuKey Laboratory of Food Quality and Safety of Jiangsu Province, State Key Laboratory Breeding Base, Nanjing 210014, China; Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing 210014, China. Electronic address: yu981190@hotmail.com.
Jiangsu Academy of Agricultural Sciences · CNNanjing Xiaozhuang University · CNUniversity of Hawaiʻi at Mānoa · US

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

Neonicotinoids (NEOs), a large class of organic compounds, are a type of commonly used pesticide for crop protection. Their uptake and accumulation in plants are prerequisites for their intra- and intercellular movements, transformation, and function. Understanding the molecular mechanisms that underpin NEO uptake by plants is crucial for effective application, which remains elusive. Here, we demonstrate that NEOs enter plant cells primarily through the transmembrane symplastic pathway and accumulate mainly in the cytosol. Two plasma membrane intrinsic proteins discovered in Brassica rapa, BraPIP1;1 and BraPIP2;1, were found to encode aquaporins (AQPs) that are highly permeable to NEOs in different plant species and facilitate NEO subcellular diffusion and accumulation. Their conserved transport function was further demonstrated in Xenopus laevis oocyte and yeast assays. BraPIP1;1 and BraPIP2;1 gene knockouts and interaction assays suggested that their proteins can form functional heterotetramers. Assessment of the potential of mean force indicated a negative correlation between NEO uptake and the energy barrier of BraPIP1;1 channels. This study shows that AQPs transport organic compounds with greater osmolarity than previously thought, providing new insight into the molecular mechanisms of organic compound uptake and facilitating innovations in systemic pesticides.

Indexed as

AquaporinsAnimalsBiological TransportBrassica rapaInsecticidesNeonicotinoidsOocytesPesticidesPlant ProteinsXenopus laevisAquaporinsInsecticidesNeonicotinoidsPesticidesPlant ProteinsaquaporinBrassica rapaneonicotinoidplasma membranesystemic pesticideuptake

Identifiers

PMID38297839
PMCPMC11121740
OpenAlexW4391343973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.