Evidence map›Paper›PMID 38297390›Full record

ArticleArthroplasty (London, England)2024

A prospective, randomized trial of liposomal bupivacaine compared to conventional bupivacaine on pain control and postoperative opioid use in adults receiving adductor canal blocks for total knee arthroplasty.

Aurora Quaye, Brian McAllister, Joseph R Garcia, Orion Nohr, Sarah J Laduzenski, Lucy Mack, Christine R Kerr, Danielle A Kerr, Charonne N Razafindralay, Janelle M Richard and 2 more

2 registry-linked trialsOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthroplasty (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05635916 phase4completednot on this map

A Prospective, Randomized Trial of Liposomal Bupivacaine Compared to Conventional Bupivacaine on Pain Control and Post-Operative Opioid Use in Receiving Adductor Canal Blocks for Total Knee Arthroplasty

TypeinterventionalSponsorNorthern Light Mercy HospitalRan2022 to 2023Enrolled80ConditionsKnee Replacement, Total Knee Arthroplasty, Post-Operative PainArmsLiposomal bupivacaine, Bupivacaine
NCT06740214 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2025 to 2028Enrolled177ConditionsPain, Postoperative, Analgesic Effect, Total Knee Arthroplasty, Liposomal BupivacaineArms0.5% standard bupivacaine only, 1.33% liposomal bupivacaine with 0.5% standard bupivacaine, 1.33% liposomal bupivacaine only
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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  7. [Observation of analgesic efficacy of liposomal bupivacaine for local infiltration anesthesia in unicompartmental knee arthroplasty: a prospective randomized controlled study].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Trial
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  9. Liposomal bupivacaine in lower extremity arthroplasty: a comprehensive review.Frontiers in pain research (Lausanne, Switzerland) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Aurora QuayeDepartment of Anesthesiology, Northern Light Mercy Hospital, 175 Fore River Parkway, Portland, ME, 04102, USA. Aurora.Quaye@spectrumhcp.com.ORCID http://orcid.org/0000-0002-7573-2164
Brian McAllisterDepartment of Anesthesiology, Northern Light Mercy Hospital, 175 Fore River Parkway, Portland, ME, 04102, USA.
Joseph R GarciaDepartment of Anesthesiology, Northern Light Mercy Hospital, 175 Fore River Parkway, Portland, ME, 04102, USA.
Orion NohrDepartment of Anesthesiology, Northern Light Mercy Hospital, 175 Fore River Parkway, Portland, ME, 04102, USA.
Sarah J LaduzenskiDepartment of Anesthesiology, Northern Light Mercy Hospital, 175 Fore River Parkway, Portland, ME, 04102, USA.
Lucy MackDepartment of Anesthesiology, Northern Light Mercy Hospital, 175 Fore River Parkway, Portland, ME, 04102, USA.
Christine R KerrDepartment of Anesthesiology and Perioperative Medicine, Maine Medical Center, 22 Bramhall St, Portland, ME, 04102, USA.
Danielle A KerrDepartment of Anesthesiology and Perioperative Medicine, Maine Medical Center, 22 Bramhall St, Portland, ME, 04102, USA.
Charonne N RazafindralayUniversity of New England College of Osteopathic Medicine, 11 Hills Beach Rd, Biddeford, ME, 04005, USA.
Janelle M RichardDepartment of Anesthesiology and Perioperative Medicine, Maine Medical Center, 22 Bramhall St, Portland, ME, 04102, USA.
Wendy Y CraigTufts University School of Medicine, 145 Harrison Ave, Boston, MA, 02111, USA.
Stephen RodrigueNorthern Light Mercy Orthopedics, 20 Northbrook Dr, Falmouth, ME, 04105, USA.
Maine Medical Center · USTufts University · USNew England College · USNorthern Light Mercy Hospital · USSpectrum Healthcare · IN

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Brenda Morissette Joly · 2017 to 2026
$51.6M
NIGMS NIH HHS U54 GM115516NIGMS NIH HHS U54GM115516
6 · The paper itself

Abstract

backgroundTotal knee arthroplasty (TKA) is a commonly performed procedure to alleviate pain and improve functional limitations caused by end-stage joint damage. Effective management of postoperative pain following TKA is crucial to the prevention of complications and enhancement of recovery. Adductor canal blocks (ACB) with conventional bupivacaine (CB) provide adequate analgesia after TKA, but carry a risk of rebound pain following block resolution. Liposomal bupivacaine (LB) is an extended-release local anesthetic that can provide up to 72 h of pain relief. The objective of this study was to compare postoperative outcomes between ACBs using LB and CB after TKA.

methodsThis single institution, prospective, randomized, clinical trial enrolled patients scheduled for TKA. Participants were randomized to receive ACB with either LB or CB. Pain scores up to 72 h postoperatively were assessed as the primary outcome. Opioid consumption and length of stay were evaluated as secondary outcomes.

resultsA total of 80 patients were enrolled. Demographic and clinical characteristics were similar between the two groups. LB group showed significantly lower cumulative opioid use during the 72 h evaluated (P = 0.016). There were no differences in pain scores or length of stay between the groups.

conclusionThe study demonstrated that LB ACBs led to significantly lower opioid consumption in the days following TKA without affecting pain scores or length of stay. This finding has important implications for improving postoperative outcomes and reducing opioid use in TKA patients. Previous studies have reported inconsistent results regarding the benefits of LB, highlighting the need for further research.

trial registrationThis project was retrospectively registered with clinicaltrials.gov ( NCT05635916 ) on 2 December 2022.

Indexed as

AnestheticsArthroplastyKneeLocalNerve blockPainPostoperativeRegional anesthesiaReplacement

Identifiers

PMID38297390
PMCPMC10832097
OpenAlexW4392787563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.