ArticleBMC pediatrics2024
Multivitamin consumption and childhood asthma: a cross-sectional study of the NHANES database.
Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 13 citations in OpenAlex.
- Association between serum vitamins and sex hormone levels in adolescent males: based on the National Health and Nutrition Examination Survey (NHANES).Hormones (Athens, Greece) · 2026Article
- Associations between fat-soluble vitamin status, growth, and development in Chinese children aged 3-14 years: a cross-sectional study.Frontiers in pediatrics · 2026Article
- Assessment of multivitamin usage and factors affecting lifestyle of community in Lahore. Pakistan: cross-sectional study.BMC nutrition · 2025Article
- Trimester and sex-specific associations of maternal thyroid profile with neonatal thyroid-stimulating hormone.Endocrine connections · 2025Article
- Relationship between eosinophil counts and carbohydrate intake in US children with asthma.BMC pediatrics · 2025Article
- Biomarker-driven drug development for allergic diseases and asthma: An FDA public workshop.The Journal of allergy and clinical immunology · 2025Article
- Vitamin C in Allergy Mechanisms and for Managing Allergic Diseases: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Dietary magnesium intake affects the association between dietary vitamin A and depression: a cross-sectional study.Frontiers in nutrition · 2025Article
- Causal Association Between 12 Micronutrients and Common Chronic Respiratory Diseases: A Bidirectional Two-Sample Mendelian Randomization Study.Genetics research · 2025Article
- The association between adult asthma in the United States and dietary total energy intake: a retrospective cross-sectional analysis from NHANES.BMC nutrition · 2024Article
- The association between the composite dietary antioxidant index and asthma in US children aged 3-18 years: a cross-sectional study from NHANES.Scientific reports · 2024Article
- Dietary choline intake in European and non-european populations: current status and future trends-a narrative review.Nutrition journal · 2024Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDietary intakes of vitamins are associated with asthma. However, previous studies mainly explored the association between a single vitamin intake and asthma, which did not take the multivitamins into consideration. Herein, this study aims to explore the overall effect of dietary multivitamins consumption on childhood asthma.
methodsData of children and adolescents (aged 2-17 years old) were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2015-2018 in this cross-sectional study. Weighted univariate logistic regression analysis was used to screen covariates. The association between multivitamins (including vitamin A, C, D, E, B1, B2, B6, B12, K, niacin, folic acid, and choline) and childhood asthma was explored using univariate and multivariate logistic regression analyses. The evaluation indexes were odds ratio (OR) and 95% confidence interval (CI). We further introduced the Bayesian kernel machine regression (BKMR) to assess the joint effect of the twelve vitamins on childhood asthma, the impact of an individual vitamin as part of a vitamin mixture, and the potential interactions among different vitamins.
resultsAmong 4,715 eligible children and adolescents, 487 (10.3%) had asthma. After adjusting for covariates including race, family history of asthma, pregnant smoking, BMI Z-score, energy intake, breast feeding, and low birth weight, we found that for each 1-unit increase in vitamin K consumption, the odds of childhood asthma decreased 0.99 (P=0.028). The overall effect analysis reported a trend of negative relationship between the multivitamins and childhood asthma, especially at the 75th percentile and over. According to the BKMR models, when other vitamins are fixed at the median level, the odds of childhood asthma increased along with the elevated vitamin D (VD) and vitamin B2 (VB2), whereas along with the depressed vitamin C (VC). In addition, no potential interaction has been found between every two vitamins of multivitamins on childhood asthma.
conclusionAmong children and adolescents who have high-risk of asthma, it may be beneficial to increase dietary consumption of multivitamins. Our findings recommended that children and adolescents should increase the intake of VC-rich foods, whereas control the dietary consumption of VD and VB2 in daily life.
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