ArticleBMC psychiatry2024
Relationship between biological rhythm dysregulation and suicidal ideation in patients with major depressive disorder.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Social Rhythms, Depressive Symptoms, and Quality of Life: An Unbreakable Bond in an Older Adult Sample.International journal of environmental research and public health · 2026Observational
- Association between biological rhythm disruption and suicidal ideation in patients with major depressive disorder: a chain mediation of neuroticism and emotion regulation difficulties.Frontiers in psychiatry · 2026Article
- Suicidality and/or Death-Related Thoughts in Health Workers After Pandemics: The Role of DYMERS.Journal of clinical medicine · 2025Article
- Association between biological rhythm disturbances and suicidal ideation in mood disorders: A cross-sectional study in China.Scientific reports · 2025Article
- Biological rhythm and depression severity mediate the relationship between adverse childhood experiences and non-suicidal self-injury among adolescents with depressive disorder.Scientific reports · 2025Article
- Role of chronotype in depression.World journal of psychiatry · 2025Review
- Impact of Pre-lockdown Hyper-energy on Mood and Rhythm Dysregulation in Older Adults During the COVID-19 Pandemic.Clinical practice and epidemiology in mental health : CP & EMH · 2025Article
- Stress, Dysregulation of Rhythms, and Bipolar Disorder: A Challenging Field of Research.Journal of clinical medicine · 2024Article
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Authors and funding
10 authors at 2 institutions in 1 country.
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Abstract
backgroundAlthough the disturbance of circadian rhythms represents a significant clinical feature of major depressive disorder (MDD), the relationship between biological rhythm disturbances and the severity of suicidal ideation in individuals with MDD remains unclear. We aimed to explore the characteristics of different biological rhythm dimensions in MDD and their association with the severity of depressive symptoms and suicidal ideation.
methodsA total of 50 MDD patients and 50 healthy controls were recruited and their general information was collected. The severity of depressive symptoms was assessed with the 17-item Hamilton Depression Rating Scale (HDRS
resultsSignificant differences were observed between the MDD group and the control group in total BRIAN score (Z=-5.41, P < 0.001) as well as scores for each dimension. After adjusting for confounding factors, multiple logistic regression analysis revealed a significant association between total BRIAN score and the presence of MDD (OR = 1.20, 95% CI = 1.10-1.29, P < 0.001), as well as between scores in different BRIAN dimensions and the presence of MDD (activity: OR = 1.47, 95% CI = 1.24-1.74, P < 0.001; sleep: OR = 1.52, 95% CI = 1.28-1.79, P < 0.001; social: OR = 1.80, 95% CI = 1.32-2.46, P < 0.001; eating pattern: OR = 1.34, 95% CI = 1.12-1.60, P = 0.001). In patients with MDD, linear regression analysis demonstrated a positive relationship between BSS scores and BRIAN eating pattern scores (β = 0.34, P = 0.022), even after adjusting for demographic factors and the severity of depression.
conclusionsPatients with MDD exhibited significantly higher levels of dysregulation in all four biological rhythm dimensions compared to healthy controls and the degree of dysregulation was associated with the severity of depression. More importantly, dysregulation of eating pattern may increase the intensity of suicidal ideation in MDD, thus elevating the risk of suicide.
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