Evidence map›Paper›PMID 38297180›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2024

Prescribing practices of inhaled corticosteroids for premature infants in the neonatal intensive care unit.

Monica Tang, Anna Ibrahim, Christopher Laughon, Kaila Moore, Angibel Tejada, Dean Tran, Ryan Kilpatrick, Rachel G Greenberg, Christoph P Hornik, Kanecia Zimmerman and 3 more

Abstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Neonatologists' practices in screening and managing corticosteroid-induced adrenal insufficiency in the NICU- a multicenter study.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Monica TangDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA. monica.tang2@ucsf.edu.ORCID 0000-0001-8847-5817
Anna IbrahimDuke Clinical Research Institute, Durham, NC, USA.
Christopher LaughonDuke Clinical Research Institute, Durham, NC, USA.
Kaila MooreDuke Clinical Research Institute, Durham, NC, USA.
Angibel TejadaDuke Clinical Research Institute, Durham, NC, USA.
Dean TranDuke Clinical Research Institute, Durham, NC, USA.
Ryan KilpatrickDuke Clinical Research Institute, Durham, NC, USA.ORCID 0000-0003-1059-2401
Rachel G GreenbergDuke Clinical Research Institute, Durham, NC, USA.ORCID 0000-0003-4156-8543
Christoph P HornikDuke Clinical Research Institute, Durham, NC, USA.
Kanecia ZimmermanDuke Clinical Research Institute, Durham, NC, USA.
Matthew M LaughonDepartment of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-4052-3215
Reese H ClarkPediatrix Center for Research and Education, Pediatrix Medical Group, Inc, Sunrise, FL, USA.ORCID 0000-0002-7363-4640
Jason E LangDuke Clinical Research Institute, Durham, NC, USA.

Funding

RESEARCH TRAINING IN ALLERGY AND CLINICAL IMMUNOLOGYT32AI007062 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David B. Peden, John W. Sleasman · 1985 to 2026
$6.1M
NIH Summer Research Experience Programs (R25)R25HD076475 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2013 to 2023
$1.1M
Mentorship of Early-Career Clinicians in Bronchopulmonary Dysplasia Drug TherapiesK24HL143283 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2019 to 2023
$613k
NHLBI NIH HHS K24 HL143283NIAID NIH HHS T32 AI007062NICHD NIH HHS R25 HD076475U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R25 HD076475-06U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32 AI007062-40
6 · The paper itself

Abstract

objectiveDespite limited safety and efficacy data, inhaled corticosteroids (ICS) are prescribed to premature infants in the neonatal intensive care unit (NICU). We examined contemporary use and risk factors for ICS use in the NICU. STUDY

designInfants <33 weeks gestational age and <1500 gm birth weight discharged from Pediatrix Medical Group NICUs between 2010 and 2020 were included. We evaluated the association between ICS prescription and clinical characteristics using univariable and multivariable logistic regression.

resultsOf 74,123 infants from 308 NICUs, 9253 (12.5%) were prescribed ICS: budesonide, fluticasone, or beclomethasone. Diagnosis of bronchopulmonary dysplasia (BPD), earlier gestational age, male sex, longer mechanical ventilation, oxygen support, and systemic steroids were independent risk factors for ICS prescription.

conclusionsUse of ICS is common in many NICUs and is associated with a diagnosis of BPD and healthcare utilization. Prospective trials are needed to establish the safety, efficacy, and optimal indication in this vulnerable population.

Indexed as

Bronchopulmonary DysplasiaInfant, PrematureIntensive Care Units, NeonatalPractice Patterns, Physicians'Administration, InhalationAdrenal Cortex HormonesBeclomethasoneBudesonideFemaleFluticasoneGestational AgeHumansInfant, NewbornLogistic ModelsMaleRetrospective StudiesAdrenal Cortex HormonesBeclomethasoneBudesonideFluticasone

Identifiers

PMID38297180
PMCPMC11226392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.