ArticleNature2024
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 203 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed, 1 pooled it
75.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
203 citing papers in PubMed, 1 synthesis or guideline pooled it, 267 citations in OpenAlex.
- Exploring the potential association and experimental validation of disrupted circadian rhythms with polycystic ovary syndrome via meta-analysis and bioinformatics: a possible pathogenic mechanism.Frontiers in endocrinology · 2025Pooled it
- Ferroptosis and tumor microenvironment: orchestrating therapy resistance, immune evasion, and metastatic events.Medical oncology (Northwood, London, England) · 2026Review
- The cGAS-STING/MITA pathway in innate antiviral immunity and beyond.Cell insight · 2026Review
- Cuproptosis and ferroptosis: signal pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Ferroptosis as a target mechanism in heart and kidney disease.The Journal of clinical investigation · 2026Review
- Role of PCSK9 in hallmarks of cancer: From mechanisms to interventions (Review).Oncology letters · 2026Review
- Histone H4 lysine 12 lactylation-driven ZIP14 expression is involved in electroacupuncture therapy against cerebral ischemia/reperfusion injury in mice.Journal of advanced research · 2026Article
- Mechanisms underlying propagation of ferroptotic cell death.Nature cell biology · 2026Review
- Ferroptotic propagation: from single-cell execution to tissue-scale death programs.Cell research · 2026Review
- Ferroptosis in T cells: mechanisms, biology and translational opportunities.Nature reviews. Immunology · 2026Review
- Unveiling the miR‑26a‑5p/MSMO1/7‑DHC Axis: A Novel Therapeutic Target in Myocardial Ischemia-Reperfusion Injury.Cardiovascular drugs and therapy · 2026Article
- Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress.The Journal of cell biology · 2026Article
- Modeling Inherited Disorders of Post-Lanosterol Cholesterol Biosynthesis: From Animal Models to Patient-Derived Stem Cells.International journal of molecular sciences · 2026Review
- From the Cosmos to the Cell: The Central Role of Iron in the Chemistry and Evolution of Life.International journal of molecular sciences · 2026Review
- Steroid Biosynthesis Pathway Counteracts Iron Overload-Induced Ferroptosis in Mouse Granulosa Cells.Biology · 2026Article
- Context-Dependent Modulation of Ferroptosis by Metformin: Mechanisms, Therapeutic Implications and Open Questions.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Untargeted Metabolomics Analysis Reveals Potential Metabolic Targets in Gemcitabine-Treated Pancreatic Cancer Cells.Metabolites · 2026Article
- Unlocking ferroptosis heterogeneity: ATF4 versus SREBF transcriptional programs.Cell death discovery · 2026Article
- Ferroptosis as an approach to leverage cancer metabolism.Trends in cell biology · 2026Review
- Article
143 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
47 authors at 16 institutions in 5 countries.
Florencio Porto Freitas *Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-0369-4488
Hamed Alborzinia *Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Ancély Ferreira Dos Santos *Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Palina NepachalovichCenter of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.ORCID 0000-0002-3404-9537
Lohans PedreraInstitute of Genetics, CECAD, University of Cologne, Cologne, Germany.
Omkar ZilkaDepartment of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0003-3534-0470
Alex InagueRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-7410-9226
Corinna KleinHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Nesrine ArouaHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Kamini KaushalHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Bettina KastHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Svenja M LorenzInstitute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.
Viktoria KunzComprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Würzburg, Germany.
Helene NehringRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Thamara N Xavier da SilvaRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-5236-8470
Zhiyi ChenRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Sena AticiRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Sebastian G DollInstitute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-8933-5362
Emily L SchaeferDepartment of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Ifedapo EkpoDepartment of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Werner SchmitzDepartment of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.ORCID 0000-0003-0485-7303
Aline HorlingInstitute of Pharmacy, Martin Luther University Halle Wittenberg, Halle, Germany.
Peter ImmingInstitute of Pharmacy, Martin Luther University Halle Wittenberg, Halle, Germany.
Sayuri MiyamotoInstituto de Química, Universidade de Sao Paulo, Sao Paulo, Brazil.
Ann M WehmanDepartment of Biological Sciences, University of Denver, Denver, CO, USA.ORCID 0000-0001-9826-4132
Thiago C Genaro-MattosMunroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, USA.
Karoly MirnicsMunroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-5521-0254
Lokender KumarFaculty of Applied Sciences and Biotechnology, Shoolini University, Himachal Pradesh, India.
Judith Klein-SeetharamanDepartment of Physics, Colorado School of Mines, Golden, CO, USA.
Svenja MeierjohannDepartment of Pathology, University of Würzburg, Würzburg, Germany.
Isabel WeigandMedizinische Klinik und Poliklinik IV, Ludwig Maximillian University, Munich, Germany.ORCID 0000-0001-5873-8567
Matthias KroissMedizinische Klinik und Poliklinik IV, Ludwig Maximillian University, Munich, Germany.ORCID 0000-0002-7628-3161
Georg W BornkammInstitute of Experimental Cancer Research, University Hospital Ulm, Ulm, Germany.
Fernando GomesInstituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0003-4642-9729
Luis Eduardo Soares NettoInstituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-4250-9177
Manjima B SathianDepartment of Pharmacy, Ludwig Maximilian University of Munich, Munich, Germany.ORCID 0000-0002-3630-3076
David B KonradDepartment of Pharmacy, Ludwig Maximilian University of Munich, Munich, Germany.ORCID 0000-0001-5718-8081
Douglas F CoveyDepartment of Developmental Biology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-9316-8683
Bernhard MichalkeResearch Unit Analytical BioGeoChemistry, Helmholtz Center München (HMGU), Neuherberg, Germany.
Kurt BommertComprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Würzburg, Germany.
Ralf C BargouComprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Würzburg, Germany.ORCID 0000-0002-1221-7421
Ana Garcia-SaezInstitute of Genetics, CECAD, University of Cologne, Cologne, Germany.ORCID 0000-0002-3894-5945
Derek A PrattDepartment of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0002-7305-745X
Maria FedorovaCenter of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.ORCID 0000-0002-4692-3885
Andreas TrumppHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.ORCID 0000-0002-6212-3466
Marcus ConradInstitute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-1140-5612
José Pedro Friedmann AngeliRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany. pedro.angeli@uni-wuerzburg.de.ORCID 0000-0001-7706-1379
University of Würzburg · DEGerman Cancer Research Center · DEHelmholtz Zentrum München · DEUniversidade de São Paulo · BRUniversity of Ottawa · CAComprehensive Cancer Center Mainfranken · DELudwig-Maximilians-Universität München · DEMartin Luther University Halle-Wittenberg · DENebraska Medical Center · USUniversity Hospital Carl Gustav Carus · DEUniversity of Cologne · DEColorado School of Mines · USShoolini University · INUniversity Hospital Ulm · DEUniversity of Denver · USWashington University in St. Louis · US
Funding
Vulnerability of DHCR7+/- mutation carriers to aripiprazole and trazodone treatmentR01MH110636 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MIRNICS, KAROLY, PORTER, NED ALLEN · 2017 to 2021
$2.7MNIMH NIH HHS R01 MH110636
Abstract
Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation
Indexed as
Burkitt LymphomaDehydrocholesterolsFerroptosisNeuroblastomaAnimalsCell SurvivalHumansLipid PeroxidationNeoplasm TransplantationOxidation-ReductionOxidoreductases Acting on CH-CH Group DonorsPeroxidesPhenotypeReproducibility of Results7-dehydrocholesterol7-dehydrocholesterol reductaseDehydrocholesterolsOxidoreductases Acting on CH-CH Group Donorsperhydroxyl radicalPeroxides
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.