ArticleNature2024
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver.
Erratum issuedOpen access · hybridAbstract read
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 139 papers.
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139citing papers in PubMed
65.9field-weighted citation impact, top 1% of its field
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Who cites it
139 citing papers in PubMed, 202 citations in OpenAlex.
- Mechanically preconditioned stem cells therapy using bioinspired liver-mimetic microspheres for functional liver repair.Bioactive materials · 2026Article
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- Transient Cytoskeletal Anisotropy Encodes Short-Term Mechanical Memory in Glioblastoma Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
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- High-Density Type I Collagen Promotes IFN-γAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immune-stromal interactions at the crossroads of tissue injury, repair, and tumor progression.Med (New York, N.Y.) · 2026Review
- The Emerging Challenge of Non-Cirrhotic MASLD-Related Hepatocellular Carcinoma: Etiology, Immunopathology, and Precision Oncology.Liver cancer · 2026Review
- Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Hepatic stellate cell subpopulations in human MASLD-related hepatocellular carcinoma upregulate YAP via geranylgeranyl pyrophosphate.Hepatology communications · 2026Article
- Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterials.Science advances · 2026Article
- Matrix degradation promotes fibronectin deposition and spatial remodeling in 3D.Cell reports. Physical science · 2026Article
- Multifrequency magnetic resonance elastography for predicting pancreatic cancer aggressiveness and patient survival.European radiology · 2026Article
- Peroxisome proliferator-activated receptor gamma (PPARγ) as a mechano-metabolic transducer: coordinating lipid homeostasis through mechanical cues.Molecular biomedicine · 2026Review
- TRIM29-dependent AKR1B10 degradation ameliorates MASH.Science advances · 2026Article
- Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review).International journal of molecular medicine · 2026Review
- Hepatocyte CD146 and soluble CD146 promote hepatic stellate cell activation via the integrin αvβ1-p38 MAPK signaling axis to drive liver fibrosis.Cellular and molecular life sciences : CMLS · 2026Article
- Traction Force Microscopy for Viscoelastic Substrates: A Semi-Analytical Method.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization.Nature materials · 2026Article
- From disease model to therapeutic insight: An engineered hydrogel reveals the role of matrix viscous dissipation in intervertebral disc degeneration.Bioactive materials · 2026Article
- Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy.MedComm · 2026Review
79 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 8 institutions in 3 countries.
Weiguo FanGastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Kolade Adebowale *Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
Lóránd Váncza *Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0295-4732
Yuan LiGastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Md Foysal RabbiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-3214-2209
Koshi KunimotoGastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Dongning ChenGastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Gergely MozesGastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
David Kung-Chun ChiuDepartment of Pathology, Stanford University, Stanford, CA, USA.
Yisi LiDepartment of Automation, Tsinghua University, Beijing, China.
Junyan TaoPittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Yi WeiGastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Nia AdenijiGastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Ryan L BrunsingDepartment of Radiology, Stanford University, Stanford, CA, USA.
Renumathy DhanasekaranGastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Aatur SinghiPittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0003-3930-7096
David GellerPittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Su Hao LoDepartment of Biochemistry and Molecular Medicine, University of California at Davis, Sacramento, CA, USA.
Louis HodgsonDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-9188-7580
Edgar G EnglemanDepartment of Pathology, Stanford University, Stanford, CA, USA.
Gregory W CharvilleDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2774-2704
Vivek CharuDepartment of Pathology, Stanford University, Stanford, CA, USA.
Satdarshan P MongaPittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0002-8437-3378
Taeyoon KimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Rebecca G WellsDepartments of Medicine and Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6988-4102
Ovijit ChaudhuriChemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.ORCID 0000-0002-9287-3401
Natalie J TörökGastroenterology and Hepatology, Stanford University, Stanford, CA, USA. ntorok@stanford.edu.ORCID 0000-0001-8074-7048
VA Palo Alto Health Care System · USStanford University · USUniversity of Pittsburgh Medical Center · USAlbert Einstein College of Medicine · USKeio University · JPPurdue University West Lafayette · USUniversity of California, Davis · USUniversity of Pennsylvania · US
Funding
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4MStanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5MPittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER · 2019 to 2026
$10.9MRole of Wnt/Beta-Catenin Signaling in Liver DevelopmentR01DK062277 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga · 2004 to 2026
$9.0MMultiplex Imaging of Signaling Pathways in Cell MotilityR35GM136226 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Louis Hodgson · 2020 to 2026
$5.3MPhagocytosis and NOX2 in Liver FibrogenesisR01DK083283 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TOROK, NATALIE J. · 2010 to 2019
$3.1MTargeting tumor metabolism and immune environment via beta-catenin: Towards precision medicine in HCCR01CA251155 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LUJAMBIO, AMAIA, MONGA, SATDARSHAN SINGH · 2020 to 2024
$3.1MInvestigating Multifactorial Beta-catenin Activation in Hepatocellular CancersR01CA250227 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Xin Chen, Satdarshan Singh Monga · 2021 to 2026
$3.0MRole of extracellular matrix malleability in mediating breast cancer cell invasion and migrationR37CA214136 · NCI · STANFORD UNIVERSITY · PI CHAUDHURI, OVIJIT · 2018 to 2024
$2.5MUniversal Roles of Force Generation and Transmission in Biological SystemsR01GM126256 · NIGMS · PURDUE UNIVERSITY · PI KIM, TAEYOON · 2017 to 2021
$2.3MMatrix in pre-cirrhotic HCCR01CA277710 · NCI · STANFORD UNIVERSITY · PI Natalie J. Torok · 2023 to 2026
$2.3MYap and beta-catenin interactions in liver: Implications in PathophysiologyR01CA204586 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, XIN, MONGA, SATDARSHAN SINGH · 2016 to 2020
$2.1MBLRD VA I01 BX002418NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA204586NCI NIH HHS R01 CA250227NCI NIH HHS R01 CA251155NCI NIH HHS R01 CA277710NCI NIH HHS R37 CA214136NIA NIH HHS R01 AG060726NIDDK NIH HHS P30 DK116074NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK062277NIDDK NIH HHS R01 DK083283NIGMS NIH HHS R01 GM126256NIGMS NIH HHS R35 GM136226NIH HHS S10 OD010580NIH HHS S10 OD032300
Abstract
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development
Indexed as
Carcinoma, HepatocellularDisease ProgressionElasticityExtracellular MatrixLiver CirrhosisLiver NeoplasmsAnimalsbeta CateninCell ProliferationCollagenComputer SimulationDiabetes Mellitus, Type 2Glycation End Products, AdvancedHumansIntegrin beta1Neoplasm InvasivenessAGER protein, humanbeta CateninCollagenGlycation End Products, AdvancedIntegrin beta1Receptor for Advanced Glycation End ProductsTensinsTNS1 protein, humanYAP-Signaling Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.