Evidence map›Paper›PMID 38297097›Full record

ArticleScientific reports2024

CD38 genetic variation is associated with increased personal distress to an emotional stimulus.

Tanya L Procyshyn, Laury-Ann Leclerc Bédard, Bernard J Crespi, Jennifer A Bartz

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tanya L ProcyshynDepartment of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK. tlp30@cam.ac.uk.
Laury-Ann Leclerc BédardDepartment of Psychology, McGill University, 2001 McGill College Avenue, Montreal, H3A 1G1, Canada.
Bernard J CrespiDepartment of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, V5A 1S6, Canada.
Jennifer A BartzDepartment of Psychology, McGill University, 2001 McGill College Avenue, Montreal, H3A 1G1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic variation in CD38-a putative oxytocin pathway gene-has been linked to higher oxytocin levels, empathy, and sensitive parenting, but also to more negative interpersonal outcomes (e.g., alienation from friends and family, poorer romantic relationship quality). To reconcile these seemingly contradictory findings, we drew upon the idea that CD38 variation may heighten social-emotional sensitivity and, consequently, make individuals prone to negative emotions in distressing interpersonal situations. To test this hypothesis, we performed a secondary analysis of a dataset including participants' (n = 171; 94 females) empathic concern ("sympathetic") and distress-related ("anxious") responses to an emotional video. Distress responses were higher for the CD38 rs3796863 AA/AC group vs. the CC group (p = 0.03, η

Indexed as

ADP-ribosyl Cyclase 1Membrane GlycoproteinsOxytocinReceptors, OxytocinEmotionsEmpathyFemaleHumansPolymorphism, Single NucleotideADP-ribosyl Cyclase 1CD38 protein, humanMembrane GlycoproteinsOxytocinReceptors, Oxytocin

Identifiers

PMID38297097
PMCPMC10831108

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.