Evidence map›Paper›PMID 38297084›Full record

ArticleMolecular psychiatry2024

SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome.

Vera Stamenkovic, Jonathan D Lautz, Felicia M Harsh, Stephen E P Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vera StamenkovicCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Jonathan D LautzCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Felicia M HarshCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Stephen E P SmithCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA. seps@uw.edu.ORCID 0000-0003-4180-573X
Center for Infectious Disease Research · US

Funding

Investigating the synaptic pathology of AutismR01MH113545 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI Stephen Edward Paucha Smith · 2018 to 2026
$5.8M
Subtyping the autisms using individualized protein network analysisR01MH121487 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI SMITH, STEPHEN EDWARD PAUCHA · 2020 to 2021
$1.4M
Protein Interaction Network Analysis to Test the Synaptic Hypothesis of AutismR00MH102244 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI SMITH, STEPHEN EDWARD PAUCHA · 2015 to 2017
$734k
NIMH NIH HHS R00 MH102244NIMH NIH HHS R01 MH113545NIMH NIH HHS R01 MH121487
6 · The paper itself

Abstract

Glutamatergic synapses encode information from extracellular inputs using dynamic protein interaction networks (PINs) that undergo widespread reorganization following synaptic activity, allowing cells to distinguish between signaling inputs and generate coordinated cellular responses. Here, we investigate how Fragile X Messenger Ribonucleoprotein (FMRP) deficiency disrupts signal transduction through a glutamatergic synapse PIN downstream of NMDA receptor or metabotropic glutamate receptor (mGluR) stimulation. In cultured cortical neurons or acute cortical slices from P7, P17 and P60 FMR1

Indexed as

BenzodioxolesDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeNeuronsProto-Oncogene Proteins c-fynsrc-Family KinasesAnimalsCerebral CortexMaleMiceMice, Inbred C57BLMice, KnockoutPhenotypeProtein Interaction MapsQuinazolinesBenzodioxolesFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Fyn protein, mouseProto-Oncogene Proteins c-fynQuinazolinesReceptors, Metabotropic GlutamateReceptors, N-Methyl-D-Aspartatesaracatinibsrc-Family Kinases

Identifiers

PMID38297084
PMCPMC11524049
OpenAlexW4391402370

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.