Evidence map›Paper›PMID 38296909›Full record

ArticleDrug delivery and translational research2024

Natural herb wormwood-based microneedle array for wound healing.

Wenqin Ding, Xingyu Shao, Sheng Ding, Yinzhou Du, Weiyong Hong, Qingliang Yang, Ying Song, Gensheng Yang

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wenqin Ding *College of Pharmaceutical Science, Zhejiang University of Technology, #18 Chaowang Road, Hangzhou, 310014, China.
Xingyu Shao *College of Pharmaceutical Science, Zhejiang University of Technology, #18 Chaowang Road, Hangzhou, 310014, China.
Sheng Ding *College of Pharmaceutical Science, Zhejiang University of Technology, #18 Chaowang Road, Hangzhou, 310014, China.
Yinzhou DuCollege of Pharmaceutical Science, Zhejiang University of Technology, #18 Chaowang Road, Hangzhou, 310014, China.
Weiyong HongDepartment of Pharmacy, Municipal Hospital Affiliated to Taizhou University, Taizhou, 318000, China.
Qingliang YangCollege of Pharmaceutical Science, Zhejiang University of Technology, #18 Chaowang Road, Hangzhou, 310014, China.
Ying SongCollege of Pharmaceutical Science, Zhejiang University of Technology, #18 Chaowang Road, Hangzhou, 310014, China. songying@zjut.edu.cn.
Gensheng YangCollege of Pharmaceutical Science, Zhejiang University of Technology, #18 Chaowang Road, Hangzhou, 310014, China. yanggs@zjut.edu.cn.ORCID 0000-0002-6127-7930
Zhejiang University of Technology · CNTaizhou Municipal Hospital · CN

Funding

National Natural Science Foundation of China 21808206National Natural Science Foundation of China 22078297
6 · The paper itself

Abstract

Artemisia argyi, commonly known as wormwood, is a traditional Chinese herbal food and medicine celebrated for its notable antibacterial and anti-inflammatory properties. This study explores a novel delivery method for wormwood, aiming for more convenient and versatile applications. Specifically, we present the first investigation into combining wormwood with microstructures to create a microneedle (MN) patch for wound healing. The wormwood microneedle (WMN) patch is formulated with milled wormwood sap, calcium carbonate, and sodium hyaluronate. The addition of 0.3% (w/v) sodium hyaluronate enhances the mechanical strength of the WMN patch. Pectin, derived from wormwood, is combined with calcium carbonate to create a gelatinous and solidified substance. The WMN patch exhibits a well-defined shape and sufficient mechanical strength to penetrate the epidermis, as confirmed by our results. In vitro experiments demonstrate the biocompatibility of the WMN patch with fibroblasts and highlight its antibacterial and anti-inflammatory properties. Furthermore, the patch facilitates collagen deposition at the wound site. In an excisional rat model, the WMN patch significantly accelerates the wound closure rate compared to the control group. Our findings suggest that the WMN patch has the potential to serve as a natural treatment for wound healing. Additionally, this approach can be extended to other biologically active substances with similar physiochemical characteristics in future applications.

Indexed as

ArtemisiaNeedlesRats, Sprague-DawleyWound HealingAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsFibroblastsHumansHyaluronic AcidMaleMicePectinsRatsAnti-Bacterial AgentsAnti-Inflammatory AgentsHyaluronic AcidPectinsAntibacterial activityArtemisia argyiWormwood microneedle patchWound healing

Identifiers

PMID38296909
OpenAlexW4391404637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.