Evidence map›Paper›PMID 38296902›Full record

ArticleOral and maxillofacial surgery2024

Survey of the association between tooth extraction and development of medication-related osteonecrosis of the jaw in patients undergoing cancer treatment with bone-modifying agents.

Mai Nozawa-Kobayashi, Hidenobu Sakuma, Hiroko Kanemaru, Akira Kurokawa, Marie Soga, Moe Yamashita, Kanae Niimi, Tadaharu Kobayashi

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In one paragraph

Article in Oral and maxillofacial surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mai Nozawa-KobayashiDivision of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Hidenobu SakumaDivision of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. h-sakuma@dent.niigata-u.ac.jp.
Hiroko KanemaruOral Management Clinic for Medical Cooperation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Akira KurokawaOral Management Clinic for Medical Cooperation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Marie SogaOral Management Clinic for Medical Cooperation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Moe YamashitaOral Management Clinic for Medical Cooperation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Kanae NiimiPatient Support Center, Niigata University Medical and Dental Hospital, Niigata, Japan.
Tadaharu KobayashiDivision of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Niigata University Medical and Dental Hospital · JPNiigata University · JPSapporo Minami Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to verify whether tooth extraction before the administration of bone-modifying agents (BMA) was effective in preventing the onset of medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND

methodsThis retrospective study included patients with a history of receiving BMA for cancer treatment. The patients were classified into three groups based on the timing of tooth extraction: no tooth extraction before the onset of MRONJ, tooth extraction before the administration of BMA, and tooth extraction after the administration of BMA. The incidence of MRONJ was compared between the groups. Fisher's exact test and Bonferroni correction were used to test for differences in proportions between the three groups.

resultsThe total number of subjects was 123. Twenty-four patients (19.5%) developed MRONJ. The incidence rates were 12.3% (10/81), 17.9% (5/28), and 64.3% (9/14) in the non-extraction group, the extraction before BMA administration group, and the extraction after BMA administration group, respectively, showing statistically significant differences between the extraction after BMA administration group and the non-extraction groups and between the extraction after BMA administration group and the extraction before BMA administration group (p < 0.001, p = 0.0049). On the other hand, there was no statistically significant difference in incidence between the non-extraction and the extraction before BMA administration group (p = 0.5274).

conclusionsTooth extraction before the administration of BMA is effective in preventing the onset of MRONJ in patients receiving BMA for cancer treatment. Prevention of MRONJ development in patients receiving BMA for cancer treatment contributes to the maintenance of patients' quality of life.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsTooth ExtractionAdultAgedAged, 80 and overDiphosphonatesFemaleHumansIncidenceMaleMiddle AgedNeoplasmsRetrospective StudiesBone Density Conservation AgentsDiphosphonatesBone-modifying agentsExtractionMedication-related osteonecrosis of the jawQuality of life

Identifiers

PMID38296902
OpenAlexW4392786426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.