Evidence map›Paper›PMID 38296868›Full record

ArticleJournal of thrombosis and thrombolysis2024

Proteomics associated with coronary high-risk plaques by optical coherence tomography.

Takayuki Niida, Haruhito Yuki, Keishi Suzuki, Daisuke Kinoshita, Daichi Fujimoto, Akihiro Nakajima, Iris McNulty, Hang Lee, Kahraman Tanriverdi, Sunao Nakamura and 1 more

Abstract read
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In one paragraph

Article in Journal of thrombosis and thrombolysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Takayuki Niida *Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Haruhito Yuki *Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Keishi SuzukiCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Daisuke KinoshitaCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Daichi FujimotoCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Akihiro NakajimaInterventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan.
Iris McNultyCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hang LeeBiostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kahraman TanriverdiDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sunao NakamuraInterventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan.
Ik-Kyung JangCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ijang@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5796-3006
Harvard University · USNew Tokyo Hospital · JPVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers are widely used for the diagnosis and monitoring of cardiovascular disease. However, markers for coronary high-risk plaques have not been identified. The aim of this study was to identify proteins specific to coronary high-risk plaques. Fifty-one patients (71.2 ± 11.1 years, male: 66.7%) who underwent intracoronary optical coherence tomography imaging and provided blood specimens for proteomic analysis were prospectively enrolled. A total of 1470 plasma proteins were analyzed per patient using the Olink® Explore 1536 Reagent Kit. In patients with thin-cap fibroatheroma, the protein expression of Calretinin (CALB2), Corticoliberin (CRH) and Alkaline phosphatase, placental type (ALPP) were significantly increased, while the expression of Neuroplastin (NPTN), Folate receptor gamma (FOLR3) and Serpin A12 (SERPINA12) were significantly decreased. In patients with macrophage infiltration, the protein expressions of Fatty acid-binding protein, intestinal (FABP2), and Fibroblast growth factor 21 (FGF21) were significantly decreased. In patients with lipid-rich plaques, the protein expression of Interleukin-17 C (IL17C) was significantly increased, while the expression of Fc receptor-like protein 3 (FCRL3) was significantly decreased. These proteins might be useful markers in identifying patients with coronary high-risk plaques. Clinical Trial Registration: https://www.umin.ac.jp/ctr/ , UMIN000041692.

Indexed as

Coronary Artery DiseasePlaque, AtheroscleroticSerpinsCoronary AngiographyCoronary VesselsFemaleHumansMalePlacentaPregnancyProteomicsTomography, Optical CoherenceSERPINA12 protein, humanSerpinsHigh-risk plaqueOptical coherence tomographyProteomicsStable angina pectoris

Identifiers

PMID38296868
OpenAlexW4391380794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.