Evidence map›Paper›PMID 38296798›Full record

ReviewOrthopaedic surgery2024

Emerging Roles of Macrophage Polarization in Osteoarthritis: Mechanisms and Therapeutic Strategies.

Zimu Yuan, Decheng Jiang, Mengzhu Yang, Jie Tao, Xin Hu, Xiao Yang, Yi Zeng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Orthopaedic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
27.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. [Research progress on immune microenvironment imbalance and targeted interventions in osteoarthritis comorbid with diabetes mellitus].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. How Selective are Nanomaterials to Treat Osteoarthritis.International journal of nanomedicine · 2026
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zimu YuanWest China Medical School, Sichuan University, Chengdu, China.ORCID https://orcid.org/0009-0006-9559-480X
Decheng JiangWest China Medical School, Sichuan University, Chengdu, China.
Mengzhu YangWest China Medical School, Sichuan University, Chengdu, China.
Jie TaoWest China Medical School, Sichuan University, Chengdu, China.
Xin HuOrthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
Xiao YangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
Yi ZengOrthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0003-1650-8020
Sichuan University · CN

Funding

Cadre Health Research Project of Sichuan Province 2023-118Department of Science and Technology of Chengdu 2023-GH02-00075-HZKey Project of Sichuan Provincial Department of Science and Technology 23ZDYF2641National key research and development program of the Ministry of Science and Technology 2023YFB4606700
6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common chronic degenerative joint disease in middle-aged and elderly people, characterized by joint pain and dysfunction. Macrophages are key players in OA pathology, and their activation state has been studied extensively. Various studies have suggested that macrophages might respond to stimuli in their microenvironment by changing their phenotypes to pro-inflammatory or anti-inflammatory phenotypes, which is called macrophage polarization. Macrophages accumulate and become polarized (M1 or M2) in many tissues, such as synovium, adipose tissue, bone marrow, and bone mesenchymal tissues in joints, while resident macrophages as well as other stromal cells, including fibroblasts, chondrocytes, and osteoblasts, form the joint and function as an integrated unit. In this study, we focus exclusively on synovial macrophages, adipose tissue macrophages, and osteoclasts, to investigate their roles in the development of OA. We review recent key findings related to macrophage polarization and OA, including pathogenesis, molecular pathways, and therapeutics. We summarize several signaling pathways in macrophage reprogramming related to OA, including NF-κB, MAPK, TGF-β, JAK/STAT, PI3K/Akt/mTOR, and NLRP3. Of note, despite the increasing availability of treatments for osteoarthritis, like intra-articular injections, surgery, and cellular therapy, the demand for more effective clinical therapies has remained steady. Therefore, we also describe the current prospective therapeutic methods that deem macrophage polarization to be a therapeutic target, including physical stimulus, chemical compounds, and biological molecules, to enhance cartilage repair and alleviate the progression of OA.

Indexed as

OsteoarthritisPhosphatidylinositol 3-KinasesAgedHumansMacrophagesMiddle AgedOsteoclastsSynovial MembranePhosphatidylinositol 3-KinasesMacrophage PolarizationOsteoarthritisSignaling Pathway

Identifiers

PMID38296798
PMCPMC10925521
OpenAlexW4391445049

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.