ArticleJournal of the National Medical Association2024
Association of cardiometabolic comorbidities with mortality among low-income Black and White Americans.
Article in Journal of the National Medical Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Prevalence and associated factors of asthma and COPD among adults in Iran based on the 2021 STEPS survey.Scientific reports · 2025Article
- Trends of cardiovascular disease and sepsis related mortality in the United States, 1999 to 2019: A CDC WONDER Database Analysis.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Joint Associations of Frailty and Cardiometabolic Diseases With Risk of All-Cause and Cardiac Mortality.JACC. Asia · 2025Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
methodsInvestigated the association of multiple cardiometabolic comorbidities with total/major cause-specific mortality and evaluate if this association might be modified by race among predominantly low-income Black and White participants.
methodsThe Southern Community Cohort Study, prospective cohort study. Participants (40-79 years) recruited predominantly from community health centers across 12 states in southeastern United States. Enrollment began in 2002 and concluded in 2009, follow-up until 2020. Cardiometabolic comorbidities (diabetes, hypertension, myocardial infarction, stroke) ascertained at the baseline survey. Cox proportional hazard models used.
resultsStudy included 76,721 participants; 16,197, 41,944, 5,247, and 4,919 participants with prior diagnosis of diabetes, hypertension, myocardial infarction, and stroke, respectively at baseline. Compared to individuals with no comorbidity, individuals with any single comorbidity experienced a significantly 30 to 90% increased rate of death due to any causes. The increase in mortality was elevated with an increasing number of comorbidities, with HR of 3.81 (95% CI: 3.26-4.46) and a cumulative risk of 62.5% at age 75 years for total mortality for those with four comorbidities. The risk was high for death due to cardiovascular diseases (HR: 6.18, 95% CI: 5.12-7.47). These associations were stronger among Blacks than Whites. Individuals with four comorbidities at age 40 years were estimated to have a 16-year loss in life expectancy compared with those without any comorbidity.
conclusionCardiometabolic comorbidities were associated with increases in all-cause and major cause-specific mortality, particularly Black Americans. This study calls for effective measures to prevent cardiometabolic comorbidities to reduce premature deaths in underserved Americans.
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