Evidence map›Paper›PMID 38296479›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Successful Treatment of Epstein-Barr Virus Reactivation-associated Transverse Myelitis Following Herpes Zoster with Intravenous Rituximab in a Cord Blood Transplant Recipient.

Keijiro Sato, Rie Watanabe, Ichiro Ito, Ken-Ich Imadome, Masahiko Sumi, Hikaru Kobayashi

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Keijiro SatoDepartment of Hematology, Nagano Red Cross Hospital, Japan.
Rie WatanabeDepartment of Neurology, Nagano Red Cross Hospital, Japan.
Ichiro ItoDepartment of Clinical Pathology, Nagano Red Cross Hospital, Japan.
Ken-Ich ImadomeDepartment of Advanced Medicine for Virus Infections, National Center for Child Health and Development, Japan.
Masahiko SumiDepartment of Hematology, Nagano Red Cross Hospital, Japan.
Hikaru KobayashiDepartment of Hematology, Nagano Red Cross Hospital, Japan.
Nagano Red Cross Hospital · JPNational Center For Child Health and Development · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Epstein-Barr virus (EBV) is associated with many malignancies and autoimmune diseases, including multiple sclerosis. In addition, EBV rarely but occasionally causes central nervous system (CNS) complications. We herein report a case of transverse myelitis (TM) associated with systemic EBV reactivation after herpes zoster infection in a cord blood transplant recipient. Identification of EBV-infected peripheral blood cells revealed a predominance of B cells. Notably, intravenous rituximab ameliorated EBV reactivation and TM. Since the CNS infiltration rate of intravenous rituximab is markedly low, the clinical efficacy of rituximab against TM suggests that EBV reactivation may cause TM via immune-mediated mechanisms.

Indexed as

Cord Blood Stem Cell TransplantationEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHerpes ZosterMyelitis, TransverseRituximabVirus ActivationAdministration, IntravenousHumansImmunologic FactorsTreatment OutcomeImmunologic FactorsRituximabautoimmuneEpstein-Barr virusrituximabtransverse myelitis

Identifiers

PMID38296479
PMCPMC11442935
OpenAlexW4391378817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.